Theoretical Study on the Conformational Conversion of 1,3-Dioxane Inside a Capsular Host  

作　　者：WANG Ju YANG Zuo-yin WANG Xiu-li ZHANG Jing-chang CAO Wei-liang 

机构地区：[1]State Key Laboratory of Chemical Resource Engineering, Faculty of Science, BeOing University of Chemical Technology, Beijing 100029, P. R. China

出　　处：《Chemical Research in Chinese Universities》2008年第2期241-245,共5页高等学校化学研究（英文版）

基　　金：Supported by the Special Research Fund for the Doctoral Program of Higher Education(No20040010008);the Scientific Research Fund of Beijing University of Chemical Technology(NoQN0411)

摘　　要：The mechanism for the conformational conversion of 1,3-dioxane guest encapsulated inside a capsular host was theoretically investigated using semiempirical PM3 method and DFT methods. The free-state process of the conformational conversion of 1,3-dioxane was also investigated to make a comparison between the two different states using the same theory. The influences of the inner phase of the capsule on the conformational conversion of guest molecule were discussed via analyzing the comparative results. It was found that the capsular host could accommodate 1,3-dioxane within its cavity by the weak attractive interactions between host and guest, and it responds to the conformational conversion of guest by the deformation of hydrogen-bonding seam at the middle of the capsule. When entrapped in the capsule, the guest molecule undergoes the conformational conversion from chair form to twist-boat form slower than that under the free condition. The deformation of the capsule is favorable to maximize the attractive interactions between host and guest.The mechanism for the conformational conversion of 1,3-dioxane guest encapsulated inside a capsular host was theoretically investigated using semiempirical PM3 method and DFT methods. The free-state process of the conformational conversion of 1,3-dioxane was also investigated to make a comparison between the two different states using the same theory. The influences of the inner phase of the capsule on the conformational conversion of guest molecule were discussed via analyzing the comparative results. It was found that the capsular host could accommodate 1,3-dioxane within its cavity by the weak attractive interactions between host and guest, and it responds to the conformational conversion of guest by the deformation of hydrogen-bonding seam at the middle of the capsule. When entrapped in the capsule, the guest molecule undergoes the conformational conversion from chair form to twist-boat form slower than that under the free condition. The deformation of the capsule is favorable to maximize the attractive interactions between host and guest.

关 键 词：Complex Cylindrical capsular host Host-guest interaction energy Quantum chemistry 

分 类 号：O626[理学—有机化学] O641.121[理学—化学]