不同减毒方法对无细胞百日咳菌苗减毒效果的比较研究  

Comparison of Five Different Chemical Detoxifying Methods on Acellular Pertussis Vaccine

作　　者：杨晓明[1] 秦力[1] 乔瑞洁[1] 刘方蕾[1] 何长民[1] 

机构地区：[1]卫生部兰州生物制品研究所

出　　处：《微生物学免疫学进展》1997年第3期22-26,共5页Progress In Microbiology and Immunology

摘　　要：采用５种不同的化学减毒方法对无细胞百日咳菌苗的ＰＴ组分减毒效果进行了比较研究，选择出对菌苗的抗原性破坏小、减毒效果确切、减毒时不产生变性蛋白凝块的改进的甲醛减毒方法。Five different chemical detoxifying methods on acellular pertussis vaccine were investigated.The results showed that the modified detoxifying method (method Ⅲ) using 0.06% formaldehyde, 0.01% protective reagent,and 0.05 M stabilizer is suitable to destroy the toxicity,protect the antigenicity of vaccine,and unform protein flocculus.

关 键 词：无细胞菌苗 百日咳菌苗 减毒 效果 鉴定 

分 类 号：R516.603[医药卫生—内科学] R392－33[医药卫生—临床医学]