含RGD的配基与其受体相互作用研究进展  

Recent Advances in Interaction Between RGD containing Ligands and Their Receptor Research .

作　　者：孙迎庆[1] 郭雁[1] 茹炳根[1] 

机构地区：[1]北京大学蛋白质工程及植物基因工程国家重点实验室,北京100871

出　　处：《生物化学与生物物理进展》1997年第2期121-126,共6页Progress In Biochemistry and Biophysics

摘　　要：RGD配基与其受体相互作用目前已成为一个研究热点 ,许多粘附蛋白是通过RGD序列与其整合素结合的 ,它参与许多生物学过程 .文章主要就RGD序列肽与糖蛋白Ⅱb/Ⅲa的相互作用及其在抑制血小板聚集上进行了较为全面的综述 。At present, more and more people are interested in studying the interaction between the receptors and their RGD containing ligands. It is generally thought that the interaction between integrins and adhesive proteins is mediated through the RGD sequence within the adhesive proteins, which may participate in many physiologic process. A major description is given on the interaction between RGD containing peptide and GpⅡb /Ⅲa and its inhibition on platelet aggregation. Also presented is the perspective of RGD containing peptides or proteins in the study of the relationship of the structure and function of protein and in the pharmaceutical field.

关 键 词：粘附蛋白 RGD 配基 受体 

分 类 号：Q510.2[生物学—生物化学]