神经节苷脂类抑制BT325细胞系的生长  

Gangliosides Inhibit Growth of Human Glioblastma Multiform Cell Line BT325

作　　者：李爱华[1] 黄如彬[1] 杨典洱[1] 金有豫[2] 

机构地区：[1]首都医科大学生物化学教研室,北京100054 [2]首都医科大学药物研究所,北京100054

出　　处：《生物化学与生物物理进展》1997年第3期242-245,共4页Progress In Biochemistry and Biophysics

摘　　要：应用自提的神经节苷脂GM 3,牛脑神经节苷脂 (bovinebraingangliosides,BBG)加入低血清培养的人多形成胶质细胞瘤BT32 5细胞中观察其对该细胞系的影响 ;以及GM3、BBG对表皮生长因子(EGF)刺激该细胞系生长的拮抗作用 .结果表明GM3、BBG均能抑制BT32 5细胞生长 ,GM 3的抑制作用远高于BBG ,其抑制率为 60 2 8% (P <0 0 1 ) ,BBG为 1 9 33% ,在含不同浓度的EGF培养液中分别加入GM3、BBG均可拮抗EGF对BT32 5生长的刺激作用 ,GM3的拮抗作用远高于BBG .Ganglioside GM3 and bovine brain Gangliosides(BBG) were added exogenously to human glioblastma multiform cell line BT325 to observe their effects on BT325. The results showed that GM3 and BBG inhibited BT325 cell growth. The maximum of cell proliferation inhibition rate of GM3 and BBG were 60 28% and 19 33%, respectively. GM3 and BBG were added to medium which has different concentration of EGF. Both GM3 and BBG inhibited the EGF-stimulated BT325 cell growth and the effects of GM3 is far stronger than BBG.

关 键 词：神经节苷脂 牛脑神经节苷脂 抑制作用 

分 类 号：Q546.02[生物学—生物化学]