HPV感染患者宫颈液基细胞学检测及组织活检在宫颈病变诊断中的价值  

The function of LCT test and histology biopsy of the patients with high risk HPV infection in diagnosis of cervical lesion

作　　者：任力[1] 侯朝晖[2] 毛志远[1] 李德昌[1] 岳颖[1] 

机构地区：[1]空军总医院病理科,北京100036 [2]空军总医院妇产科,北京100036

出　　处：《中国妇幼保健》2008年第12期1724-1728,共5页Maternal and Child Health Care of China

摘　　要：目的:评估HPV检测、液基细胞学及阴道镜下组织活检在宫颈病变普查中的价值及意义。方法:对在我院妇产科门诊就诊病人进行液基细胞学检查,对宫颈细胞学阳性者进行HPV检测,并对其中HPV阳性的患者进行阴道镜下宫颈组织活检,分析我院门诊HPV感染患者宫颈病变的发病情况。结果:我院门诊就诊患者HPV的感染率为8.03%(846/10542),HPV阳性患者细胞学LSIL以上阳性率为66.1%(559/846),组织学CINⅠ以上阳性率为72.6%(614/846),两者统计学比较无显著性差异(P>0.05)。结论:宫颈病变的发生集中在生育及性活跃期,即年龄31～40岁为发病高峰。宫颈病变的发生与高危型HPV感染密切相关,HPV高危型以HPV16、18型为最常见类型。液基细胞学检查辅以HPV检测及阴道镜下活检可以大大提高宫颈病变的诊断率。Objective： To evaluate the function and significance of high risk HPV test, LCT test and histology biopsy with histology. Methods： The patients were detected by LCT in outpatient department of gynecology, the patients of cervical LCT test positive were detected by HPV test, then the patients with HPV test positive were histology biopsy with colposcopy and the patients cervical lesion with HPV infection were analyzed in outpatient in this hospital. Results： HPV infection percentage of out patient in this hospital was 8. 3% （846/10 542）, the positive percentage of HPV positive patients above LCT LSIL was 66. 1% （559/846）, the positive percentage of histo- loty biopsy above CIN I was 72. 6% （614/846）, there was no significant deviation between two methods （P 〉0. 05） . Conclusion.. Cervical lesion concentrates upon child -bearing age and sex activety period, the peak 31 - 40 years. The cervical lesion is related to high risk HPV infection and the most common risk HPV types are HPV 16, 18. The positive percentage of cervical lesion diagnosis is significant elevated with LCT to assist HPV test and histology biopsy with colposcopy.

关 键 词：细胞学检查 HPV—DNA 宫颈病变 

分 类 号：R446[医药卫生—诊断学]