半胱氨酸蛋白酶抑制剂C在儿童早期肾病诊断中的应用  

Serum cystatin C as an early diagnostic marker in children with renal diseases

作　　者：张晓洁[1] 徐华国[1] 葛高霞[1] 

机构地区：[1]南京医科大学第一附属医院,江苏省妇幼卫生保健中心检验科,210036

出　　处：《江苏医药》2008年第4期351-353,共3页Jiangsu Medical Journal

摘　　要：目的比较血清半胱氨酸蛋白酶抑制剂C（CYC）和血清肌酐（SCr）、尿素在儿童早期肾病诊断中的检测灵敏度，并研究健康儿童血CYC水平变化规律。方法采用微粒子免疫增强比浊法测定64例肾脏病患儿血清CYC浓度，同时用酶法平行测定血清SCr和尿素浓度，比较三者检测的敏感性差异。测定106例0～14岁正常儿童（包括23例脐带血）血清CYC浓度以确定儿童的参考值范围。结果肾脏病患儿CYC的阳性率为59．4％（38／64）；SCr的阳性率为25．0％（16／64），血清尿素的阳性率为12．5％（8／64），CYC与SCr和尿素间存在显著性差异（P〈0．01）。结论CYC检测在儿童早期肾病诊断中比血清SCr和尿素灵敏。Objective To compare the sensitivity of serum cystatin C （CYC） with serum creatinine（SCr） and blood urea in children with renal disease and investigate the CYC level in healthy children during different stages of diseases. Methods Sixty-four children with renal diseases were collected in this study. Serum CYC was measured by microparticle enhanced nephelometry, serum SCr and urea were measured by enzyme-analysis method. The results were compared with regard to their differences in sensitivity. Meanwhile, 106 healthy children aged from 0 to 14 years old were also studied as normal controls to determine the normal range of CYC. Results The sensitivity of CYC in patient group was 59.4%（38/64） ,which was higher than that of both SCr （25.0%, 16/64） and urea （12.5%, 8/64） （P〈 0.01）. Conclusion CYC is more sensitive than SCr and Urea in the early diagnosis of renal disease.

关 键 词：半胱氨酸蛋白酶抑制剂C 血清肌酐 血清尿素 肾小球滤过率 

分 类 号：R551[医药卫生—血液循环系统疾病]