SDF-1、CXCR4在乳腺癌组织及转移淋巴结中的表达及其意义  

Expression and significance of SDF-1 and CXCR4 in human breast cancer tissues and metastatic lymph nodes

作　　者：沈恩超[1] 凌立君[1] 王水[1] 刘晓安[1] 朱海清[2] 李凤山 

机构地区：[1]南京医科大学第一附属医院乳腺外科,210029 [2]南京医科大学附属脑科医院病理科 [3]南京市妇幼保健医院病理科

出　　处：《江苏医药》2008年第4期367-369,F0003,共4页Jiangsu Medical Journal

基　　金：江苏省"六大人才高峰"重点资助项目(2006-B-070);江苏省博士后基金(0601048B)

摘　　要：目的探讨基质细胞衍生因子(SDF-1)及其受体CXCR4在乳腺癌原发灶和腋窝转移淋巴结中的表达对判断乳腺癌预后的价值。方法采用免疫组化SP法检测SDF-1和CXCR4在50例乳腺癌组织、26例腋窝转移淋巴结和正常乳腺组织标本10例中的蛋白表达,并进行相关性分析。结果SDF-1在乳腺癌组织和正常乳腺组织中阳性表达率分别为90%和70%(P>0.05);CXCR4在乳腺癌组织和正常组织中阳性表达率分别为72%和10%(P<0.01)。SDF-1、CXCR4在淋巴结阳性组表达高于淋巴结阴性组(P<0.01);且26例腋窝淋巴结转移的患者转移淋巴结和原发灶中SDF-1、CXCR4均呈高表达。结论趋化因子SDF-1及其受体CXCR4的表达与乳腺癌发生、发展密切相关,推测其可作为判断乳腺癌患者一个有价值的预后指标。Objective To investigate the expre.ssion and prognostic value of stromal cell-derived factor-1（SDF-1）and CXCR4 receptor in human breast cancer tissues and axillary metastatic nodes. Methods SDF-1 and CXCR4 were detected in 50 breast cancer tissues （group A）, 26 axillary metastatic nodes （group B） and 10 control groupbreast tissues（group C） by immunohistochemistry. Results Positive rates of SDF-1 in group A and group C were 90% and 70%, respectively （P〉 0. 05）. Positive rates of CXCR4 in group A and group C were 72% and 10%, respectively （P〈0.01）. Expression of SDF-1 and CXCR4 in breast cancer tissues with axillary lymph node metastasis was higher than that in breast cancer tissues without axillary lymph node metastasis, which was closely associated with axillary lymph node metastasis （P 〈 0. 01 ）. Postitive rate of SDF-1 and CXCR4 in axillary metastatic nodes was as high as in primary lesion. Coneausion Expressions of SDF-1 and CXCR4 may have a close relationship with tumor growth and metastasis of breast cancer. It may be taken as a valuable marker for evaluating prognosis of the patients with breast cancer.

关 键 词：乳腺癌 基质细胞衍生因子1 CXCR4 淋巴结转移 

分 类 号：R655[医药卫生—外科学]