微波辐射法合成5-取代四唑衍生物  

Synthesis of 5-Substituted Tetrazole Derivatives under Microwave Irradiation

作　　者：彭梦侠[1] 陈梓云[1] 

机构地区：[1]嘉应学院化学系,广东梅州514015

出　　处：《中国医药工业杂志》2008年第4期249-250,共2页Chinese Journal of Pharmaceuticals

基　　金：广东省科技厅计划项目(2006B36703005)

摘　　要：在微波辐射条件下,2-氰基吡啶、3-氰基吡啶或氰基吡嗪和叠氮钠在氯化锌催化下,以水为溶剂快速制得5-(2-吡啶基)-1H-四唑、5-(3-吡啶基)-1H-四唑或5-(2-吡嗪基)-1H-四唑,收率为84%～90%。5-（2-Pyridyl）-1H-, 5-（3-pyridyl）- or 5-（2-pyrazinyl）-1H-tetrazole were synthesized in water from the corresponding nitriles and sodium azide under microwave irradiation with zinc chloride as catalyst with yields of 84% - 90%.

关 键 词：5-(2-吡啶基)-1H-四唑 5-(3-吡啶基)-1H四唑 5-(2-吡嗪基)-1H四唑 微波辐射 合成 

分 类 号：O626.28[理学—有机化学]