pH及温度双重敏感性聚(N-异丙基丙烯酰胺-烯丙胺)纳米水凝胶的制备与表征  

Preparation and Characterization of Temperature and pH Sensitive Poly(N-Isopropylacrylamide-co-allylamine) Nanohydrogel

作　　者：陈海燕[1,2] 张建[1] 胡育筑[2] 顾月清[1] 

机构地区：[1]中国药科大学生命科学与技术学院,生物医学工程研究室 [2]中国药科大学基础部分析化学教研室,江苏南京210009

出　　处：《中国医药工业杂志》2008年第4期265-268,共4页Chinese Journal of Pharmaceuticals

基　　金：国家自然科学基金项目(30371362,30672015)

摘　　要：利用聚合沉淀法制备聚(N-异丙基丙烯酰胺-烯丙胺)(PNIPA-co-NH2)纳米水凝胶。考察了其粒径分布,并以500nm处的透光率表征PNIPA-co-NH2的低临界溶解温度(LCST,Tc)和pH敏感性。结果表明,通过调节表面活性剂十二烷基硫酸钠用量和烯丙胺单体的投料比可控制纳米水凝胶的粒径和Tc。标记上荧光素后,PNIPA-co-NH2的紫外光谱发生明显改变。Poly（N-isopropylacrylamide-co-allylamine） （PNIPA-co-NH2） nanohydrogel were prepared by precipitation polymerization method. The mean size was measured by laser particle size analyzer. Transmittance at 500nm was utilized to characterize temperature and pH sensitivity of the nanohydrogels, The results showed that the size and lower critical solution temperature （LCST, Tc） of the nanohydrogel could be controlled by adjusting the amount of surfactant sodium dodecyl sulphate and allylamine monomer. After labeling with fluorescein, the ultraviolet spectra of PNIPA-co-NH2 nanohydrogel was obviously changed.

关 键 词：聚(N-异丙基丙烯酰胺-丙烯胺) 纳米水凝胶 温度敏感 PH敏感 

分 类 号：R944.9[医药卫生—药剂学]