过氧化物酶体增殖体激活受体-γ2基因Pro12Ala多态性与肥胖的关系  

Association of Pro12Ala mutation in peroxisome proliferator-activated receptor-γ_2 with obesity in Chinese population

作　　者：艾智华[1] 房殿春[1] 张忠辉[2] 

机构地区：[1]第三军医大学西南医院全军消化病研究所,重庆400038 [2]第三军医大学西南医院内分泌科,重庆400038

出　　处：《第三军医大学学报》2008年第8期691-693,共3页Journal of Third Military Medical University

基　　金：国家“十五”攻关项目(2001BA702B01,2001BA702B04)~~

摘　　要：目的探讨过氧化物酶体增殖体激活受体-γ2(PPAR-γ2)基因外显子2的Pro12Ala多态性与肥胖的关系。方法运用多聚酶链式反应-限制性片段长度基因多态性(PCR-RFLP法)分析方法,对116例超重或肥胖患者和89例正常对照者PPAR-γ2基因Pro12Ala多态性位点进行基因分型。结果超重或肥胖组Ala等位基因频率(11.64%)显著高于正常对照组(5.06%),在所检测人群中,PA/AA基因型者具有更高的体质量指数和血浆甘油三酯水平(P<0.05)。结论PPARγ2的Pro12Ala变异与肥胖的发生有关,12Ala更易发生肥胖。Objective To investigate the polymorphism of peroxisome proliferator-activated receptors-γ2 （PPAR-γ2） and its association with obesity in Chinese population. Methods According to BMI, 89 subjects who are in normal body weight range and 116 overweighted and obese subjects were included in this study. Their Pro12Ala mutation in the PPAR-γ2 gene was detected by PCR restriction fragment length polymorphism. Results Allele frequency of Ala mutation of PPAR-γ2 in overweighted and obese subjects （ qA = 11.64% ） was significantly higher than that of normal body weight group （qA = 5.06% , P 〈 0. 05 ）. Both in overweighted and obese subjects and normal body weight subjects, these with genotype of PA （AA） had higher body mass index and plasma TG than those with the genotype of PP （ P 〈 0. 05 ）. Conclusion Pro12Ala mutation in PPAR-γ2 is associated with obesity. The people with the genotype of 12Ala are likely to be obese.

关 键 词：过氧化物酶体增殖体激活受体-γ2(PPAR-γ2) 基因多态性 肥胖 

分 类 号：R181.331[医药卫生—流行病学] R394.1[医药卫生—公共卫生与预防医学]