脂类组学及神经脂类组学进展  

Progress in lipidomics and neurolipidomics

作　　者：马小琼[1] 刘广义[2] 杨军[2] 

机构地区：[1]浙江大学医学院病理及病理生理教研室,浙江杭州310058 [2]浙江大学公共卫生学院毒理系,浙江杭州310058

出　　处：《中国药理学与毒理学杂志》2008年第2期156-160,共5页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金资助项目(30471956);国家自然科学基金资助项目(30600220);霍英东基金会青年教师基金资助项目(101036);教育部新世纪人才支持计划资助项目(NCET-05-0520)~~

摘　　要：脂类组学是代谢组学的一个分支,它是用系统的方法分析所有的脂类,与它们相互作用的分子,以及它们在生物体内的作用的一个研究领域。脂类分子的生物学重要性被大量与脂类代谢和分布异常有关的疾病所证实。随着软电离技术以及新的分离技术的发展和应用,脂类的测定已经能够快速、高通量和精确地进行。脂类在神经系统中大量存在且种类众多,应用神经脂类组学技术能揭示神经系统中复杂的脂类组成及其在疾病中的变化,结合基因组学和蛋白质组学,神经脂类组学对神经系统疾病的发生机制的解释将会更加全面。Lipidomics, a branch of metabolomics, is a systems based study of all lipids, the molecules with which they interact, and their functions within the cell. The physiological importance of lipids is demonstrated by many diseases caused by abnormal lipid metabolism. With the development and application of soft ionization mass spectrometry and new separation techniques, the rapid and accurate determination of a variety of lipid species with minimal sample preparation has become feasible, which greatly accelerates lipidomic studies. Lipids exist abundantly in nervous system and have many species. Complex lipids in nervous system and the changes of lipids in diseased individual could be determined by using neurolipidomics tech-nique. Combined with genomics and proteomics, neurolipidomics could reveal the mechanisms of nervous system diseases more completely.

关 键 词：脂类组学 神经脂类组学 脂类 质谱技术 

分 类 号：Q54[生物学—生物化学]