慢性高原心脏病血清内源性洋地黄因子水平及其意义  

LEVELS OF SERUM ENDOGENOUS DIGITALIS LIKE FACTOR IN PATIENTS WITH HIGH ALTITUDE CHRONIC CARDIOPATHY AND THEIR SIGNIFICANCE

作　　者：李英悦[1] 薛增军[1] 罗登晨[1] 

机构地区：[1]成都军区拉萨总医院

出　　处：《解放军医学杂志》1997年第4期266-267,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：对１９例慢性高原心脏病（ＨＡＣＣ）患者及２９名长期移居高原健康成人（对照组）血清内源性洋地黄因子（ＥＤＦ）含量用放射免疫法进行了检测。结果发现ＨＡＣＣ患者血清ＥＤＦ浓度明显低于对照组（Ｐ＜０．０５～０．０１），并与ＰａＯ２呈正相关（ｒ＝０．６７４，Ｐ＜０．０１），与心功能指数Ｐ／Ｌ值呈负相关（ｒ＝－０．６３６，Ｐ＜０．０１）。表明慢性低氧导致ＥＤＦ分泌不足可能在ＨＡＣＣ患者心功能降低及心力衰竭的发生、发展中起重要作用。Serum endogenous digitalis like factor (EDF) was determined in 19 patients with high altitude chronic cardiopathy (HACC) by using radioimmunoassay and compared with 29 healthy subjects (as control). All of them have emigrated to Lhasa (altitude 3658m)for a long time. The results showed that serum EDF decreased significantly( P <0 05 0 01) in the patients with HACC compared with the control, and there existed a significant positive correlation with PaO 2 ( r =0 674, P <0 01),also a significant negative correlation with PEP/LVET ( r = 0 636 P <0 01). It is suggested that the decrease of EDF play an important role in the development of chronic heart failure in patients with HACC.

关 键 词：高海拔病 洋地黄因子 内源性 心力衰竭 充血性 

分 类 号：R541.9[医药卫生—心血管疾病]