气相色谱法测定冠心膏中樟脑、冰片和薄荷脑含量  

Determination of Camphor and Menthol and Borneolum syntheticum in Guanxin Plasters by GC

作　　者：田永庆 

机构地区：[1]河北省沧州市药品检验所,河北沧州061001

出　　处：《中国药业》2008年第8期36-37,共2页China Pharmaceuticals

摘　　要：目的探讨冠心膏中樟脑、冰片和薄荷脑含量的测定方法。方法采用气相色谱(GC)法,色谱柱为PEG-20M弹性石英毛细管色谱柱(30m×0.53m m×1μm),检测器为FID检测器。结果樟脑的线性进样量范围为0.095～0.95μg(r=0.9997,n=5),平均回收率为99.5%,RSD为1.9%;薄荷脑的线性进样量范围为0.123～1.23μg(r=0.9996,n=5),平均回收率为98.6%,RSD为2.0%;冰片的线性进样量范围为0.202～2.02μg(r=0.9997,n=5),平均回收率为99.4%,RSD为4.4%。结论G C法简便、快速、准确、重现性好,可以用于冠心膏的质量控制。Objective To developing a wethod for determine the contents of camphor, menthol and borneolum syntheticum in Guanxin Plasters. Methods GC was conducted on a HP - INNOWAX column（30 m ×0.53 mm × 1μm） and naphthalene was adopted. The determinater was FID. Results Camphor showd a good linear relationship in the range of 0.095-0.95 μg, （r = 0.999 7, n = 5）. Menthol showd a good linear relationship in the range of 0. 123 - 1.23 μg, （ r = 0. 999 6, n = 5）. Borneolum syntheticum showd a good linear relationship in the range of 0.202-2.02 μg,（r=0.9997, n=5）.The average recovery rate was 99. 5% fir canogir（RSD=1.9%）,98.6% for menthol （RSD = 2.0% ） and 99.4% for borneolum syntheticum（RSD =4.0% ）, respectively. Conclusion The method is simple, rapid, accurate and reliable. It can be used for the quality control of Guanxin Plasters.

关 键 词：气相色谱法 樟脑 冰片 薄荷脑 冠心膏 含量测定 

分 类 号：R284.1[医药卫生—中药学] R286.0[医药卫生—中医学]