Synthesis and cercaricidal activities of a serial of novel self-diffused cercaricides derived from niphensamide  

作　　者：Wei Guo Lv Yin Zheng Yong Quan Wu Xiao Lin Fan 

机构地区：[1]Key Laboratory of Organo-pharmaceutical Chemistry of Jiangxi Province,Gannan Normal University,Ganzhou 341000,China

出　　处：《Chinese Chemical Letters》2008年第4期406-408,共3页中国化学快报（英文版）

基　　金：the financial support from National Natural Science Foundation of China(Nos.50478117,50568001);Supports from the invite public important bidding project of Jiangxi province(2006);science foundation of Jiangxi provincial Department Education(No.GJJ08385)are also acknowledged.

摘　　要：A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae larvae.These compounds were derived from niphensamide.While the compounds were dropped on the surface of water,the liquor diffused along the air-water interface and formed thin membranes floating on the water surface immediately.The strong cercaricidal activities against the cereariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.A serial of novel cercaricides that can self-diffuse on the water surface were designed and synthesized according to the special habit of cercariae larvae.These compounds were derived from niphensamide.While the compounds were dropped on the surface of water,the liquor diffused along the air-water interface and formed thin membranes floating on the water surface immediately.The strong cercaricidal activities against the cereariae larvae of Schistosome japonicum of these compounds have been revealed by further experiments.

关 键 词：Niphensamide Self-diffused cercaricide Cercariae larvae 

分 类 号：TQ453[化学工程—农药化工]