Synthesis of benzocycloheptene derivatives as CCR5 antagonists with potent anti-HIV activity  

作　　者：Yao Liu Jing Su Jun Hai Xiao Shi Bo Jiang Hong Lu Wu Zhong Li Li Wang Xiao Hong Yang Song Li 

机构地区：[1]School of Pharmacy,Jilin University,Changchun 130021,China [2]School of Pharmacy,Shanghai Jiaotong University,Shanghai 200240,China [3]Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China [4]Lindsley E Kimball Research Institute,The New York Blood Center,New York,NY 10021,USA

出　　处：《Chinese Chemical Letters》2008年第4期428-430,共3页中国化学快报（英文版）

基　　金：supported by the National Basic Research Program of China(No.2004CB518908);the National Natural Science Foundation of China(No.30472093)to SL;the Outstanding Overseas Chinese Scholars Fund of Chinese Academy of Sciences(No.2005-2-6)to SJ.

摘　　要：A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ^1H-NMR. These compounds exhibited potent anti-HIV-1 activities.A series of novel benzocycloheptene derivatives have been synthesized.Their structures were confirmed by MS and ^1H-NMR. These compounds exhibited potent anti-HIV-1 activities.

关 键 词：HIV-1 entry inhibitors Benzocycloheptene derivatives SYNTHESIS 

分 类 号：R512.91[医药卫生—内科学] R914[医药卫生—临床医学]