川芎嗪对实验性血瘀症家兔肠系膜微血管血液动力学的影响  

The Experimental Study of the Effectiveness of Tetramethylpyrazine in Blood-quickening and Stasis-removing

作　　者：狄柯坪[1] 白芬兰[1] 贾向春[1] 李珊[1] 梁冰锋[1] 刘元昀[1] 

机构地区：[1]白求恩军医学院,石家庄050081

出　　处：《白求恩军医学院学报》2008年第2期75-77,共3页Journal of Bethune Military Medical College

摘　　要：目的在活体情况下观察川芎嗪对实验性血瘀症家兔肠系膜微血管血液动力学的影响。方法用显微闭路摄录像系统分别观察血瘀症前后家兔肠系膜微血管口径、血流速度、血流量等的改变及川芎嗪对上述指标造成的影响。结果川芎嗪可以通过增加微血管的开放数量、加快微血管内血流速度等途径增加血瘀症时肠系膜微血管内血液的灌注,起到活血化瘀的作用,但川芎嗪对微血管口径的改变没有直接作用。结论川芎嗪通过改善微循环而发挥抗血瘀症的作用。Objective To evaluate the effectivenss of tetramethylpyrazine in blocd-quickening and stasis-removing of vasomotion in rabbit mesentary. Methods The male rabbits were divided into control group （7） and tetramethylpyrazine group （7）, For control group O. 9 % NS was venous transfusion at 10 gutt/min 30 min before operation, right after operation, 12 hours after operation. For tetramethylpyrazine group, 0. 1 ml/kg tetramethylpyrazine was injected simutaneously. The diameter of capillary, red blood cell velocity and blood flow rate were studied with microscope and imaging processing system. Results Both of the number of capillary and the red blood cell velocity was increased respectively in tetramethylpyrazine group comparing to control group, but the diameter of capillary was not increased. Conclusion Tetramethylpyrazine has significantly prospective effect in blood stasis.

关 键 词：川芎嗪 家兔 微循环 血液动力学 

分 类 号：R331.3[医药卫生—人体生理学]