表面脱钙骨基质明胶诱导成骨修复颅骨大面积缺损的实验研究  

Experimental study on osteoinduction of surface decalcified bone matrix gelatin for repairing large skull defects

作　　者：李明善[1] 马开明[1] 

机构地区：[1]河南大学神经生物学研究所,河南开封475004

出　　处：《河南大学学报（医学版）》2008年第1期50-52,共3页Journal of Henan University:Medical Science

摘　　要：目的:寻找替代自体骨移植修复颅骨大面积缺损的理想材料。方法:用表面脱钙骨基质明胶修复大鼠颅骨8 mm的圆形缺损,术后不同时间行x线、组织学检查。结果:表面脱钙骨基质明胶具有诱导成骨能力,保留骨的部分生物力学特性,但完全被新骨替代时间较长。结论:表面脱钙骨基质明胶是修复大面积颅骨缺损的理想材料。Objective： To search for the ideal substitutes for autografi in repairing large skull defects. Methods： An 8mm in diameter damage of the Rat＇s skull was repaired by surface decalcified bone matrix gelatin（SDBMG）, X-ray and histological examination were performed at different period after uperatinn. Results： Surface decalcified bone matrix gelatin has the ability of osteoinduction, and pnrtional characteristic of biomechanical strength, but it needed longer time to be replaced completely by new bone. Conclusion： SDBMG is an ideal material for repairing large skull defects.

关 键 词：表面脱钙骨基质明胶 诱导成骨 颅骨 

分 类 号：R329.4[医药卫生—人体解剖和组织胚胎学]