FS-1272滴眼液对大鼠亚硒酸钠性白内障的影响  

Pharmacodynamics Study of FS-1272 Gutta in Lens of Rats with Cataract Induced by Sodium Selenite

作　　者：王晶[1] 

机构地区：[1]浙江中医药大学,杭州310053

出　　处：《浙江中医药大学学报》2008年第2期172-173,共2页Journal of Zhejiang Chinese Medical University

基　　金：上海新药研究开发中心横向课题(No:65086)~~

摘　　要：[目的]观察FS-1272滴眼液对大鼠亚硒酸钠性白内障的作用及作用机理。[方法]采用大鼠亚硒酸钠性白内障模型,观察大鼠晶状体混浊程度,测定晶状体中超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱苷肽过氧化酶(GSH-px)活性以及丙二醛(MDA)、可溶性蛋白(WSP)和不溶性蛋白(WIP)含量。[结果]FS-1272滴眼液能降低大鼠晶状体浑浊程度,增强SOD、CAT、GSH—px活性,同时降低MDA、不可溶性蛋白含量,升高可溶蛋白含量。[结论]FS-1272滴眼液可减轻晶状体氧化损伤程度,从而起到延缓白内障的发生和发展的作用。[Objective] To study the effect and mechanism of action of FS-1272 gutta on cataract of rats induced by sodium selenite. [Method] By using themodel of cataract of rats induced by sodium selenite to observe the cataract opaque degree, the activities of SOD,CAT and GSH-px,the level of MDA,WSP and WIP. [Results] FS-1272 gutta can cause cataract opaque degree in rats decreased, the activities of SOD,CAT,GSH-px increased, and the level of MDA and insolubility protein decreased, level of solubility protein increased. [Conclusion]The FS-1272 gutta has the effect of delaying cataract to happen and develop by lessening the extent of the oxidative damage of lens.

关 键 词：白内障 亚硒酸钠 超氧化物歧化酶 过氧化氢酶 丙二醛 谷胱苷肽过氧化酶 可溶性蛋白 不溶性蛋白 

分 类 号：R285.6[医药卫生—中药学]