鼠龄对大鼠去卵巢骨质疏松模型的影响  

The effect of age on the osteoporosis induced by ovariectomy in rats

作　　者：唐存贵[1] 李灵芝[1] 金鑫[1] 张新宁[1] 吕琪[1] 

机构地区：[1]武警医学院药物化学教研室,天津300162

出　　处：《中国骨质疏松杂志》2008年第4期229-232,共4页Chinese Journal of Osteoporosis

基　　金：天津市自然科学基金课题(033609811);武警总部科研基金课题(WKH2004-8)

摘　　要：目的探讨鼠龄对大鼠去卵巢后骨质疏松的影响。方法3月龄和6月龄Wistar雌性大鼠各16只,分别分为去卵巢组和假手术组。去卵巢组行双侧卵巢切除,6个月后,测定大鼠骨密度、骨矿含量、股骨生物力学和股骨远端形态结构的变化。结果与假手术组相比,去卵巢组全身及脊柱骨密度、骨矿盐含量、股骨最大压缩载荷、最大压缩应力、弹性模量均明显下降(P<0.01);骺板下骨小梁结构排列稀疏,骨小梁间的连接性变差,总量明显减少,6月龄组更明显。结论3月龄和6月龄大鼠去卵巢6个月,均可发生骨质疏松症。6月龄大鼠骨质疏松程度更严重。Objective To explore, the effect of age on the osteoporosis induced by ovariectomy in rats. Methods Each sixteen Wistar female rats about throe or six months old, were divided into sham operation group and ovariectomized group respectively. The ovariectomized groups underwent bilateral ovariectomy by dorsal approach. Six months after surgery, the rats bone mass density, bone mineral content, biomechanics proporties of femurs and morphosis of distal femurs were measured to assess osteoporosis. Results Compared to corresponding sham operation group, the ovariectomized rats had a significantly decreases in body and spine BMD, BMC, maximum compress load, maximum compress stress and elastic modulus of femurs （ P 〈 0.01 ）, the morphosis of trabecula under epiphyseal plate in distal femur was raritas ; the conjunction of trabecular was worsen, and the volume of trabecular decreased significantly. The six months old rats lost more bone than that in throe months old rats. Conclusion Six months after surgery, both throe months and six months old rats developed osteoporosis. The six months old rats had lost more bone.

关 键 词：骨密度 生物力学 形态结构 去卵巢 骨质疏松症 

分 类 号：R965[医药卫生—药理学] R589.5[医药卫生—药学]