男性海洛因依赖者认知功能状况与氧化应激的关系  

Cognitive Deficits and Oxidative Stress in Male Patients with Heroin Dependence

作　　者：李武[1] 郝伟[2] 胡春凤[1] 张向晖[2] 周绪辉[2] 谌伟文 李龙飞[1] 成义仁[1] 

机构地区：[1]山东省济宁市精神病防治院,济宁272051 [2]中南大学湘雅二医院精神卫生研究所,长沙410011 [3]湖南省新开铺劳教所,长沙410009

出　　处：《中国心理卫生杂志》2007年第3期151-154,共4页Chinese Mental Health Journal

基　　金：国家重点基础研究专项经费973项目(003CB515400);2004中南大学研究生教育创新工程项目(040143)

摘　　要：目的:探讨男性海洛因依赖者认知功能状况及其与氧化应激的关系。方法:运用韦氏记忆量表(WMS)、划销测验(CT)、威斯康星卡片分类测验(M-WCST)对140例MPHD及75例正常对照进行认知功能评估,用化学比色法检测受试血清一氧化氮(NO)与丙二醛(MDA)等氧化应激指标水平。结果:1.海洛因依赖者组WMS测验、CT及M-WCST成绩均差于对照组(MQ:93.7±13.8/102.9±12.3,t=-2.83,CT总净分:161.6±32.8/194.4±26.5,t=-4.28,WCST分类正确数:18.8±7.8/25.0±7.5,t=-3.38,P<0.01);2.MPHD血清丙二醛水平高于对照组(3.5±1.0/3.0±0.5,t=2.23,P<0.05),总抗氧化能力(114.6±15.8/118.2±16.6,t=-2.25)、维生素C、超氧化物歧化酶水平低于对照组(P<0.05或P<0.01);3.MPHDNO水平与记忆商(MQ)呈负相关(r=-0.36,P<0.05),血清MDA水平与MQ呈负相关(r=-0.42,P<0.01),血清SOD水平与MQ呈正相关(r=0.41,P<0.01)。结论:海洛因依赖者存在明显的认知功能损害与氧化抗氧化反应失衡;血清NO、MDA、SOD可能是与认知功能密切相关的氧化应激指标。Objective： To explore the relationship between cognitive deficits and oxidative stress in male patients with heroin dependence （MPHD） . Methods： The cognitive function of 140 MPHD and 75 healthy controls were evaluated with Wechsler Memory Scale （ WMS） , Cancellation Test （ CT） and Modified Wisconsin Card Sorting Test （M- WCST） . The levels of serum nitric oxide （NO） and malondialdehyde （MDA） were detected in colorimetry. Results： The performances of WMS, CT and M - WCST in MPHD were significantly lower than that in healthy controls （93.7±13.8/102.9 ± 12.3, t = -2.83; 161.6 ± 32. 8/194.4 ±26.5, t = -4.28; 18.8±7.8/25.0 ± 7.5, t = - 3.38, P 〈 0. 05 or P 〈 0. 01 ） . Compared with healthy controls, MPHD had higher serum MDA level （ 3.5 ± 1.0/3.0 ± 0. 5, t = 2. 23 , P 〈 0.05 ）, but lower total antioxidative capacity （ T - AOC, 114. 6 ± 15.8/118. 2 ± 16. 6, t = - 2. 25, P 〈0.05 ）, vitamin C （ VC ） and superoxide dismutase （ SOD） levels （ P 〈 0. 05 or P 〈 0. 01 ） . The serum NO level was negatively correlated to memory quotient （ MQ ） （ r = - 0. 36, P 〈 0.05 ） . The serum MDA level was negatively correlated to MQ （r = -0.42, P 〈 0.01 ） . Significant positive correlations were found between serum SOD level and MQ （r =0.41, P 〈 0. 01 ） . Conclusions： MPHD suffered from cognitive dysfunction and oxidative and anti-oxidative unbalance. Serum NO, MDA and SOD may be responsible for impaired cognition of MPHD.

关 键 词：物质依赖 病例对照研究 海洛因 认知功能 氧化应激 

分 类 号：R595.5[医药卫生—内科学] B842.1[医药卫生—临床医学]