尿沉渣Wright染色观察狼疮肾炎治疗前后白细胞尿的变化及其意义  

To Explore the Urinary Leucocytes Changes in Patients with Lupus Nephritis by Wright Stain

作　　者：肖青[1] 李香玲[1] 张琳琳[1] 郭振涛[1] 陈静[1] 张希燕[1] 李凯[1] 

机构地区：[1]潍坊医学院附属医院肾内科,山东潍坊261031

出　　处：《潍坊医学院学报》2008年第1期19-21,I0004,共4页Acta Academiae Medicinae Weifang

摘　　要：目的对狼疮肾炎患者治疗前后进行尿沉渣Wright染色,探讨狼疮肾炎白细胞尿的变化及其临床意义。方法对76例尿中出现白细胞的狼疮肾炎患者,分别在狼疮治疗前后留取新鲜中段尿进行细菌定量培养,应用相差显微镜进行尿沉渣细胞学检查及1h尿白细胞计数,观察狼疮肾炎治疗前后的尿液中白细胞的变化。结果7例已婚狼疮肾炎患者清洁中段尿培养为大肠杆菌,其余69例尿细菌培养为阴性。经激素及CTX治疗以后狼疮肾炎病情缓解,尿中白细胞明显减少(P<0.01)。结论狼疮肾炎活动期可以出现非感染性白细胞尿,尿中白细胞数的变化,可以作为观察狼疮肾炎疗效的一个客观指标。Objective To explore the clinical significance of urinary leucocytes changes in patients with lupus nephritis （LN） by wright stain. Methods Seventy-six LN patients with urinary leucocytes were assigened to collect mid-stream clean urine for bacterial quantitative cuhivation and were distinguished urinary sediments cell type by phase contrast microscope. One hour count of urinary leucocytes were computed also pre-and post -treatment. Results Bacterium colitis were cultivated in 7 married patients. The results of bacterial cuhivation of other 69 cases were negative. The urinary leucocytes were reduced markedly post-treatment with prednisore and CTX （ P 〈0.01 ）. Conclusion Noninfective leucocytes in urine may appear in patients with active LN. The variation of number of leucocytes in urine may be used to evaluation the treatment effect.

关 键 词：狼疮肾炎 系统性红斑狼疮 白细胞尿 

分 类 号：R593.242[医药卫生—内科学]