维生素D受体基因多态性与糖耐量异常、2型糖尿病相关性研究  

Association of Vitamin D Receptor Gene Polymorphism with Igt and Type 2 Diabetes Mellitus

作　　者：翟木绪[1] 刘芬[1] 陈希平[1] 吕祖英[1] 潘丽[1] 

机构地区：[1]日照市人民医院内分泌科,山东日照276800

出　　处：《潍坊医学院学报》2008年第1期47-49,I0004,共4页Acta Academiae Medicinae Weifang

摘　　要：目的探讨维生素D受体(vitamin D receptor,VDR)基因ApaI酶切位点多态性与糖耐量异常、2型糖尿病的相关性。方法采用聚合酶链反应限制性片段长度多态性(PCR-RFLP)技术,检测86例新发2型糖尿病(DM)患者、98例糖耐量异常患者和120例糖耐量正常者的VDR基因型,比较3组间VDR基因型和等位基因频率的分布差异。结果3组患者维生素D受体基因型分布存在显著性差异(χ2=8.471,P<0.05)。其中,糖耐量异常组患者基因型分布频率与其他两组比较,差异具有显著性(χ2=6.527,P<0.05);3组患者等位基因频率总体分布差异有显著性(χ2=7.212,P<0.05),其中,糖耐量异常组患者等位基因频率与其他两组相比差异具有显著性(χ2=5.985,P<0.05)。结论对应于ApaI位点的VDR基因多态与糖耐量异常存在相关性,但与2型糖尿病相关性不明显。Objective To investigate the association of vitamin D receptor gene polymorphism and IGT and type 2 diahetes. Methods The polymerase chain reaction-restriction fragment length polymorphism was used to delect VDR genotype in 86 newly diagnositic type 2 diabetic patients,98 IGT patients and 120 normal controls and the alleles frequencies and genotype frequencies of VDR gone were compared between these three groups. Results There was significant difference in the distrubution of VDR genolype frequencies and alleles frequencies among these three groups,the prevalence of VDR gene genotype frequencies and alleles frequencies in IGT patients was significantly different from thai in other groups. Conclusion ApaI polymorphism of VDR gene is associated with IGT and not with type 2 diabetes.

关 键 词：维生素D受体 基因多态性 糖耐量异常 

分 类 号：R977.24[医药卫生—药品]