血、尿常规检查在系统性红斑狼疮诊治中的临床意义  

CLINICAL SIGNIFICANCE OF BLOOD AND URINE RT IN SYSTEMIC LUPUS ERYTHEMATOSUS

作　　者：郑文军[1] 刘京平[1] 何钠[1] 林有坤[1] 梁伶[1] 严煜林[1] 

机构地区：[1]广西医科大学第一附属医院皮肤性病科,南宁530021

出　　处：《广西医科大学学报》2008年第1期32-35,共4页Journal of Guangxi Medical University

基　　金：广西科学基金资助项目(No桂科自0342009-5)

摘　　要：目的:探讨血尿常规检查在系统性红斑狼疮(SLE)诊治中的临床意义。方法:将700例首次住院病例根据SLEDAI计分按病情分为基本无活动组、轻度活动组、中度活动组及重度活动组,进行系统性回顾分析。结果:血常规检测显示贫血发生率(67.86%)最高;各病情活动组间红细胞、血红蛋白和血小板的减少水平差异均有统计学意义(P<0.05)。尿常规检测显示尿蛋白和尿潜血阳性率分别为40.71%、29.00%,24h尿蛋白异常率为84.30%。治疗后白细胞、红细胞、血小板、血红蛋白水平均明显好转。结论:①大多数SLE患者早期就有肾脏受累,24h尿蛋白定量分析在诊断SLE肾脏病变的敏感性比常规尿蛋白定性更高;②白细胞水平与SLE病情活动度未见明显关联。红细胞、血红蛋白、血小板可能可以作为判断SLE病情活动程度及评定治疗反应的重要参考指标。Objective：To summarize clinical significance of blood and urine routine examination in Systemic Lupus Erythematosus. Methods： 700 SLE cases of initial hospitalization were divided into 4 groups according to the disease activity based on SLEDAI： basically inactive group, slightly active group, medially active group and heavily active group and analyzed in retrospective blood and urine routine examination of the disease, degree of disease activity and initial symptoms, etc. Result： In the blood RT, the anemic incidence rate（67. 86%）was the highest. The RBC and HG were significantly different in their levels in different groups（ P 〈0.05）. The positive rates of the urine protein and urine occult blood（OB）in the urine RT were respectively 40.71% ,29.00%. Abnormity rate of the 24 hours urine protein（24 hUPr） was 84.30%. Conelusion：（1）In the most SLE patients the kidney damage is the most familiar in the earlier period; the sensitivity of the 24 hUPr quantitative analysis is higher than the qualitation of urine protein in the urine RT. （2） The level of the WBC has no obvious correlation with the disease activity degree of SLE. The RBC,HB and PLT are the important indexes to assess the treatment response.

关 键 词：红斑狼疮 系统性 血常规 尿常规 

分 类 号：R593.2[医药卫生—内科学]