一种用CT值评估大鼠股骨骨量的方法  

A Method to Evaluate Femoral Bone Mass in Rats with CT Numbers

作　　者：彭亮[1] 王洪凯[1] 刘加成[1] 尚禹[1] 白净[1] 

机构地区：[1]清华大学生物医学工程系,北京100084

出　　处：《生物医学工程学杂志》2008年第2期231-234,共4页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(60571013);教育部博士点基金资助项目(20050003090)

摘　　要：为建立一种基于CT值(Hounsfield unit,HU)的骨量评估方法,HU体积均值(HUm)被定义用来描述骨量,用于失重骨丢失的研究。尾部悬吊实验中10根大鼠股骨用于CT扫描,基于这些CT数据计算了股骨整体、近端、中段和远端的HUm,并和相应部位用DXA测量的骨密度(BMD)进行了回归分析。当HU阈值为400时,BMD和HUm的相关性股骨整体最好(R=0.887,P<0.001),股骨近端的相关性(R=0.833,P<0.01)好于股骨中段(R=0.683,P<0.05)和远端(R=0.744,P<0.05)的相关性。HU体积均值与BMD具有良好的线性关系,能够精确的描述骨量,可以用于评估大鼠尾部悬吊实验结果。To develop a method of evaluating bone mass with CT numbers （Hounsfield unit, HU）, volumetric mean of CT numbers （HUm} was defined to describe bone mass for the study of bone loss caused by microgravity. Ten femurs in the tail-suspended rats experiment were scanned by CT scanner. And the HUm of the intact, proximal, middle and distal femurs were obtained from these CT data. Then regressive analysis was performed between HUm and bone mineral density （BMD） measured by DXA in those regions. When HU threshold is equal to 400, the correlation between BMD and HUm of the intact femur is the best in all cases （R =0.887,P〈0.001）, and the correlation between BMD and HUm of the proximal femur （ R = 0.833, P 〈 0.01 ） is better than those of the middle femur （ R = 0.683, P 〈 0.05 ） and distal femur （R =0.744,P〈0.05）. Volumetric mean of CT numbers has a good linear relationship with BMD; it can accurately describe bone mass and can be used to evaluate the results of the tail-suspended rats experiment.

关 键 词：CT值 骨量 骨密度 尾部悬吊 

分 类 号：R310[医药卫生—基础医学]