纳米羟基磷灰石/脂肪族聚酯酰胺复合材料  

A Novel Nano-hydroxyapatite/aliphatic Polyesteramide Composite

作　　者：邓霞[1] 陈治清[1] 钱志勇[2] 刘彩兵[2] 李虹 

机构地区：[1]四川大学华西口腔医学院口腔材料教研室,成都610041 [2]四川大学材料科学与工程学院,成都610065 [3]金琴牙科管理公司,成都610041

出　　处：《生物医学工程学杂志》2008年第2期378-381,392,共5页Journal of Biomedical Engineering

基　　金：国家高技术研究发展计划(863计划)课题资助项目(2002AA326080)

摘　　要：在本实验中,水热合成的纳米羟基磷灰石(n-HA)作为无机相与新型的可降解的脂肪族聚酯酰胺(PEA)按不同比例复合。PEA及其复合材料的结构、性能通过透射电镜、红外光谱、X线衍射、扫描电镜及原子能谱等检测表征。结果表明,形貌尺寸相似于天然骨组织磷灰石结晶的纳米羟基磷灰石晶体均匀分散于PEA有机基质中,复合材料的两相间存在分子间作用力,提高了复合材料的力学性能。同时体外细胞学实验表明该材料具有良好的细胞相容性,显示了该复合生物材料在组织工程支架材料方面的应用前景。Hydrotherrnally synthesized nano-hydroxyapatite （n-HA） varying in weight from 10% to 30% was used as filler to make nanocomposites with novel aliphatic polyestemmide （PEA） in our latx）ratory. The structure and properties of PEA and its n-HA composites were investigated through transmission electron microscopy, infrared spectrometry, X-ray diffractioin, scanning electron microscopy and energy spectrometry. The shape and size of the n-HA crystals are similar to those of the apatite crystals in natural bone. Molecule interactions are present between the n-HA and PEA in the composite, which allows the uniform dispersion of n-HA in PEA matrix. This contributes enhanced mechanical property and bioacfivity to the composite. The cytocompatibility of the composites has been investigated by culturing osteoblasts on the Cood cell attachment and proliferation manner were observed on the membranes after 1 week. These results suggest that the PEA/n-HA composites prepared in this study may serve as potential candidate scaffold for tissue engineering.

关 键 词：纳米羟基磷灰石 聚酯酰胺 纳米复合材料 成骨细胞 

分 类 号：R318.08[医药卫生—生物医学工程]