国产无佐剂人用Vero细胞狂犬病疫苗接种反应及免疫效果  

Adverse Reaction and Immune Effect of Domestic Adjuvant-free Rabies Vaccine Prepared with Vero Cells

作　　者：刘华章[1] 黄桂花[1] 曹庆[1] 潘淮[1] 

机构地区：[1]广州市疾病预防控制中心,广州510080

出　　处：《中国生物制品学杂志》2008年第4期327-328,共2页Chinese Journal of Biologicals

摘　　要：目的观察国产无佐剂人用Vero细胞狂犬病疫苗接种反应及免疫效果。方法对93名观察对象采用0、3、7、14和28 d程序进行暴露后免疫,观察免后30 min的即时反应及72 h内的局部和全身副反应,并于第1针免疫后3、7、14和45 d采血,检测血清抗体水平。结果疫苗接种后均无异常反应,局部及全身一般反应率分别为5.8%和4.5%。免后7 d,血清抗体阳转率达22.58%,14 d达100%;免后7、14和45 d的GMT差异有显著意义;不同性别间免后14和45 d的GMT差异均无显著意义;不同年龄组间GMT14 d差异有显著意义,45 d差异无显著意义。结论国产无佐剂人用Vero细胞狂犬病疫苗安全,免疫效果好。Objective To observe the adverse reaction and immune effect of domestic adjuvant-free rabies vaccine prepared with Vero cells.Methods Immunize 93 subjects with domestic adjuvant-free rabies vaccine prepared with Vero cells on days 0,3,7,14 and 28 after exposure respectively. Observe the immediate adverse reaction within 30 rain as well as local and systemic adverse reactions with in 72 h after immunization. Collect the serum samples on days 3,7,14 and 45 respectively for determination of antibody. Results No immediate adverse reaction was observed. The incidences of local and systemic adverse reaction were 5.8% and 4.5 % respectively. The serum antibody positive conversion rate was 22.58% on day 7 and reached 100% on day 14. The GMTs of serum antibody were 2.12 and 8.52, and 15.43 IU/ml on days 7,14 and 45 respectively,which showed significant difference.The GMTs on days 14 and 45 of female and male subjects showed no significant difference. The GMTs of various age groups showed significant difference on day 14 while no significant difference on day 45. Conclusion The domestic adjuvant-free rabies vaccine prepared with Vero cells was safe and showed good immune effect.

关 键 词：狂犬病 无佐剂疫苗 VERO细胞 接种反应 免疫效果 

分 类 号：R373.9[医药卫生—病原生物学]