核不均一核糖核蛋白功能与疾病关系的研究进展  

Progress in the Study of Heterogeneous Nuclear Ribonucleoprotein and Its Relation with Diseases

作　　者：陈尧[1] 王亦男[1] 周宏灏[1] 

机构地区：[1]中南大学湘雅医学院临床药理研究所,长沙410078

出　　处：《生理科学进展》2008年第2期109-113,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金资助课题(30572226)

摘　　要：核不均一核糖核蛋白(heterogeneous nuclear ribonucleoprotein,hnRNPs)是人体广泛表达的一类蛋白,该蛋白家族与人体健康密切相关,hnRNPs参与了多种疾病的发生过程,如病毒疾病、肿瘤疾病、自身免疫性疾病等;hnRNPs也参与了特异基因的调节,如cyp2a5、CYP2A6、eNOS等;机体内物质纷繁,且hnRNPs又与其他物质之间存在千丝万缕的联系,因此需要进一步加强对hnRNPs与相关疾病发病机制以及对特异基因调节机制的研究,揭开其中的奥秘。Heterogeneous nuclear ribonucleoprotein （hnRNPs） is a widely expressing protein family in human body,which has a close relationship with health. HnRNPs takes part in the developing processes of many diseases such as viral diseases, tumor, autoimmune system diseases and so on. hnRNPs also regulates the expression of special genes such as cyp2a5 , CYP2A6 , eNOS. There are numerous proteins in vivo and hnRNPs linkes with them in numerous ways. Much work is needed to unclose the relationship between hnRNPs and related diseases or gene regulation.

关 键 词：核不均-核糖核蛋白 病毒 肿瘤 免疫 药物代谢酶 

分 类 号：Q2[生物学—细胞生物学] S823.2[农业科学—畜牧学]