肿瘤相关糖基结合蛋白Galectin-3及其治疗性配体  

Cancer-associated Carbohydrate-Binding Protein Galectin-3 and Its Therapeutic Ligands

作　　者：白卉[1] 刘莉[1] 李宇华[1] 游宇[2] 梅其炳[1] 

机构地区：[1]第四军医大学药学系药理学教研室 [2]第四军医大学唐都医院神经外科,西安710038

出　　处：《生理科学进展》2008年第2期129-134,共6页Progress in Physiological Sciences

摘　　要：糖类参与细胞间黏附、细胞与胞外基质黏附、细胞间特异性识别等过程。Galectin-3是哺乳动物体内存在的非酶类蛋白质,其结构上保守的碳水化合物识别结构域能优先与β-半乳糖苷类结构结合,参与生理生化反应。含有半乳糖苷或类似结构的物质,包括化学修饰糖类、功能多肽、天然改性糖类,作为galectin-3的配体,能不同程度地干预糖基和蛋白质的相互作用,抑制在肿瘤生长、侵袭和转移中具有重要作用的细胞间识别和黏附等过程。Carbohydrates are proved to be involved in recognition processes, including adhesion between cells, adhesion of cells to the extracellular matrix, and specific recognition of cells by one another. Galeetin-3 is a nonenzymatie carbohydrate-binding protein present in mammals, whose conserved carbohydrate-recognition domain preferentially binds to specific carbohydrate structures and plays an important role in biological and biochemical reactions. Substances developed with the specific structure of β-galactose moieties or their analogues, including chemically modified carbohydrates, functional peptides and modified natural polysaeeharide, have been evaluated as potent therapeutic ligands for galectin-3 and showed at different level their ability to interfere with carbohydrate-protein interactions and therefore, inhibit the cell-cell recognition and adhesion processes, which play an important role in tumor growth, progression and metastasis.

关 键 词：GALECTIN-3 配体 肿瘤 治疗作用 

分 类 号：R96[医药卫生—药理学]