蛋白质组学在附睾研究中的应用  

The Application of Proteomics in Epididymis Researches

作　　者：邹美[1] 王海丰[2] 胡建民[1] 

机构地区：[1]沈阳农业大学,沈阳110161 [2]抚顺市动物疫病预防控制中心,辽宁抚顺113006

出　　处：《生理科学进展》2008年第2期139-144,共6页Progress in Physiological Sciences

摘　　要：蛋白质组学是在后基因组时代出现的一个新的研究领域,它从整体水平对蛋白质的表达和功能模式进行分析。附睾是精子成熟和贮存的场所,因其基因表达呈现出高度的区域特异性,可能成为蛋白质组学,尤其是差异蛋白质组学研究的一个理想模型。本文主要对不同物种的附睾蛋白质组以及附睾不同区域的差异表达蛋白的研究进展予以综述,期望为附睾功能研究及开发新型男性避孕药带来新的思路和方法。Proteomics, a hot new research area studied by biologists in the post-genome era, leads an integrated study of the expression and function of proteins on a large scale. Epididymis is responsible for the sperm maturation and storage, and its gene expression is highly region-specific, so it maybe an ideal model for proteomics, especially for differential proteomics study. This paper gives a brief introduction of the application of proteomics in the epididymis and the differential proteins expressed in different epididymal regions. These epididymis-specific/selective proteins identified by proteomics technology may prove to be targets for contraception or may provide insight to the unique responsibilities of the epididymis in supporting male fertility.

关 键 词：蛋白质组学 附睾 质谱成像 激光捕获显微切割 

分 类 号：R331[医药卫生—人体生理学]