饮用水有机提取物对大鼠脂质过氧化影响  

THE EFFECTS OF ORGANIC EXTRACT OF DRINKING WATER ON LIPID PEROXIDATION OF RATS

作　　者：聂木海[1] 张全新[1] 朱伟[1] 夏清林[1] 梁晓芸[1] 

机构地区：[1]广州市疾病预防控制中心,广州510080

出　　处：《现代预防医学》2008年第8期1551-1551,1555,共2页Modern Preventive Medicine

摘　　要：[目的]观察饮用水有机提取物对大鼠脂质过氧化影响。[方法]给大鼠分别经腹腔一次注入相当于5.0L/kg、10L/kg、20L/kg饮用水的有机提取物,同时设对照组,6d后断头处死动物,测定肝、肾、睾丸组织中SOD(超氧化物歧化酶)活性和MDA(丙二醛)含量。[结果]随饮用水有机提取物浓度的升高,大鼠肝组织中SOD活性呈降低的趋势,而MDA含量则呈上升的趋势,大鼠肾、睾丸组织中SOD活性、MDA含量没明显变化。各剂量组与对照组比较差异均无统计学意义(P﹥0.05)。[结论]在本实验条件下,没发现饮用水有机提取物对机体脂质过氧化产生显著影响。[ Objective] To observe the effect of organic extract of drinking water on the lipid peroxidation of rats. [Methods] All rats were treated with intraperitoneal injection of organic extract of 5.0 L/kg, 10.0 L/kg, 20.0 L/kg drinking water. Meanwhile 10 rats were recruited as controls. After 6 weeks, all the rats were sacrifieed by decapitation. The contents of malondialdehyde （MDA） and activity of superoxide dismutase （SOD） in liver, kidney and testis of rats were detected. [Results] With the inereased contents of organic extract in drinking water, the activity of SOD in liver tissue appeared to be decreased, while the eontents of MDA were showed to be increased. The activity of SOD and contents of MDA did not showed marked change. There were no signifieantly difference between different dose of subgroups and control group （P〉 0.05）. [Conclusion] Under the experimental circumstance, there were no significant effect of organic extract of drinking water on the lipid peroxidation of organism.

关 键 词：饮用水有机提取物 SOD MDA 

分 类 号：R123[医药卫生—环境卫生学]