ACE、eNOS G894T多态性与厄贝沙坦降压疗效的关系  

RELATIONSHIP OF ANGIOTENSIN CONVERTING ENZYME INSERT/DELETE AND ENDOTHELIAL NITRIC OXIDE SYNTHASE G894T GENE POLYMORPHISMS WITH THE CURATIVE EFFECT OF IRBESARTAN IN REDUCTION OF BLOOD PRESSURE

作　　者：梁茜[1] 杨希立[1] 杨光[2] 崔金环[2] 

机构地区：[1]广东省佛山市第一人民医院心血管内科,佛山528000 [2]广东省佛山市第一人民医院临床研究所

出　　处：《现代预防医学》2008年第8期1592-1593,共2页Modern Preventive Medicine

摘　　要：[目的]探讨高血压病患者血管紧张素转换酶插入/缺失多态性和内皮型一氧化氮合酶G894T基因多态性是否与血管紧张素Ⅱ受体拮抗剂(厄贝沙坦)降压疗效相关。[方法]符合WHO/ISH高血压诊断标准的轻、中度高血压患者130例,服用厄贝沙坦单药治疗4周,在临床观察疗效的同时,用基因芯片技术对患者ACEI/D、eNOSG894T基因型进行分析。[结果]含ACED等位基因的患者服用厄贝沙坦后,收缩压下降幅度明显大于I型基因型患者,两者之间差异有统计学意义(P﹤0.05);eNOSG894T各基因型之间血压下降幅度差异均无统计学意义(P﹥0.05)。[结论]ACEI/D基因多态性与厄贝沙坦类药物的降压疗效有一定相关性。[Objective] To approach whether the angiotensin converting enzyme insertion/deletion （ACE I/D） and endothelial nitric oxide synthase gene G894T polymorphisms have association with the curative effect of Angiotensin Ⅱ receptor antagonist （irbesartan） in reduction of blood pressure. [ Methods] 130 patients which were diagnosed as light and moderate hypertension which was in line with the diagnostic criteria of WHO/ISH, were treated with irbesartan for four weeks and to observe their curative effect, the ACE I/D and eNOS G894T genotypes were detected by using gene chip technology. [ Results] When compared with patients with ACE I genotype, the contractive pressure of patients with ACE gene D allele showed significandy decreased after using irbesartan （P 〈 0.05 ）. The descending range of blood pressure did not found significant difference among patients with different types of eNOS G894T genotypes （P 〉 0.05）. [ Conclusion ] ACE/D gene polymorphism showed significant association with the curative effect of irbesartan in reduction of blood pressure.

关 键 词：高血压 厄贝沙坦 基因多态性 治疗 

分 类 号：R972.6[医药卫生—药品]