蜜炙黄芪的化学成分研究  

Chemical constituents of processed Astragalus membranaceus Bunge

作　　者：刘巍[1] 王志成[1] 梁菲菲[1] 李铣[1] 王金辉[1] 

机构地区：[1]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中国药物化学杂志》2008年第2期142-146,157,共6页Chinese Journal of Medicinal Chemistry

基　　金：新世纪优秀人才支持计划项目(NCET-04-0289)

摘　　要：目的研究蜜炙黄芪的化学成分。方法采用大孔吸附树脂柱色谱、硅胶柱色谱、制备薄层色谱、重结晶、凝胶柱色谱、HPLC制备柱色谱等手段,以体积分数70%乙醇提取,从蜜炙黄芪中分离得到7个化合物;利用理化性质和波谱学分析鉴定它们的化学结构。结果与结论分离鉴定了7个皂苷类化合物,分别为大豆皂苷Ⅰ甲酯(1)、黄芪皂苷Ⅰ(2)、黄芪皂苷Ⅱ(3)、异黄芪皂苷Ⅰ(4)、异黄芪皂苷Ⅱ(5)、黄芪皂苷Ⅲ(6)、β-胡萝卜苷(7)。化合物1为首次从该种植物中分离得到的已知化合物。Aim To study the chemical constituents of processed Astragalus membranaceus. Methods Seven compounds from the 70 % ethanol extracts were isolated by macroporous resin, silica gel, preparative TLC, recrystallization, sephadex LH-20, preparative HPLC, etc., and their structures were identified by the spectral analysis and chemical properties. Results and conclusion Seven compounds were isolated and identified as soyasaponin Ⅰ methyl ester（ 1 ）, astragaloside Ⅰ（2）, astmgaloside Ⅱ （3）, isoastragaloside Ⅰ（4）, isoastragaloside Ⅱ （ 5 ）, astragaloside Ⅲ （6）, β-sitosterol（7）.

关 键 词：蜜炙黄芪 结构鉴定 柱色谱 波谱分析 

分 类 号：R284[医药卫生—中药学]