儿茶酚胺对兔离体培养黄体细胞孕酮生成的影响  

Effect of Catecholamines on Progesterone Production by Cultured Rabbit Luteal Cells in Vitro

作　　者：崔秀志 张业[1] 马青年[1] 

机构地区：[1]哈尔滨医科大学生理学教研室

出　　处：《哈尔滨医科大学学报》1990年第5期323-327,共5页Journal of Harbin Medical University

摘　　要：本文用兔离体黄体细胞培养方法,观察了儿茶酚胺(肾上腺素、去甲肾上腺素、异丙基肾上腺素及多巴胺)和其受体阻断剂心得安及酚妥拉明对黄体细胞孕酮生成的影响。结果表明,本实验所用儿茶酚胺类物质对离体黄体细胞孕酮生成有极明显的刺激作用,β受体阻断剂心得安可显著抑制儿茶酚胺促孕酮生成作用。α受体阻断剂酚妥拉明并不抑制肾上腺素、异丙基肾上腺素,而抑制去甲肾上腺素和多巴胺对黄体细胞孕酮生成的促进作用。提示儿茶酚胺对黄体细胞孕酮生成的影响,可能与肾上腺素能β受体和α受体有关。The purpose of the present study was to investigate the effect of catecholamines and β-antagonist propranolol or α-antagonist phentolamine on progesterone by cultured rabbit luteal cells in vitro. The results showed that the hCG stimulated a dose-related increase in progesterone by rabbit luteal cells in vitro. The catecholamines tested all markedly stimulated progesterone production, and propranolol prevented the stimulation of progesterone production, phentolamine had no effect on epinephrine and isoproterenol, but inhibited effect of norepinephrine and dopamine on the progesterone production by rabbit luteal cells in vitro. Collectively these results suggest that the effect of catecholamines on progestrone production may be associated with both the β and the α-adrenergic receptors.

关 键 词：儿茶酚西安 孕酮 黄体细胞 心得安 

分 类 号：R339.22[医药卫生—人体生理学]