^18F-FDG PET—CT双时相显像对非小细胞肺癌肺门纵隔淋巴结转移的诊断价值  

Significance of dual-time-point ^18F-FDG PET imaging in evaluation of hilar and mediastinal lymph node metastasis in non-small-cell lung cancer

作　　者：胡漫[1] 于金明[1] 刘宁波[1] 刘兰平[1] 郭洪波[1] 杨国仁[2] 张品良[1] 徐晓庆[1] 

机构地区：[1]山东省肿瘤医院放疗科,济南250117 [2]山东省肿瘤医院核医学科,济南250117

出　　处：《中华肿瘤杂志》2008年第4期306-309,共4页Chinese Journal of Oncology

摘　　要：目的探讨^18F-FDG PET-CT双时相显像对非小细胞肺癌（NSCLC）肺门、纵隔淋巴结转移的诊断价值。方法选取经病理确诊拟行手术治疗的NSCLC患者46例，术前行^18F—FDG PET—CT常规全身显像和胸部延迟显像，计算标准摄取值（SUV）和储留指数（RI）。结果46例患者共切取584枚肺门及纵隔淋巴结，术后病理显示，有31例患者的134枚淋巴结出现转移，而常规显像淋巴结转移为189枚，双时相显像为161枚。双时相显像诊断淋巴结转移的敏感度、特异度、准确度、阳性预测值和阴性预测值分别为94．8％、92．2％、92．8％、78．9％和98．1％，高于常规显像时的指标（87．3％、84．0％、84．8％、61．9％和95．7％）。结论^18F-FDG PET—CT双时相显像诊断NSCLC肺门、纵隔淋巴结转移具有较高的敏感度、特异度和准确度，可为NSCLC的诊断、分期和治疗提供更多有价值的信息。Objective To explore the diagnostic value of dual-time-point ^18F-FDG PET-CT imaging in detecting hilar and mediastinal lymph node metastasis in non - small - cell lung cancer （ NSCLC ） . Methods Forty-six patients with NSCLC underwent standard whole body single-time ISF-FDG PET-CT scans and a delayed imaging for the thorax alone before surgery, meanwhile, the standard uptake value （SUV） and retention index （RI） were calculated. Results A total number of 584 lymph nodes were excised in the 46 patients. Of these, 134 metastatic lymph nodes were pathologically confirmed in 31 patients. There were 189 lymph nodes detected and suspected to be metastatic by standard single-time ^18F-FDG PET-CT imaging, and 161 by dual-time-point imaging. Therefore, the sensitivity, specificity, diagnostic accuracy, positive predictive value and negative predictive value in the detection of hilar and mediastinal lymph node metastasis were 87.3%, 84.0%, 84.8%, 61.9% and 95.7% by standard single-time ^18F-FDG PET-CT imaging, versus 94.8%, 92.2%, 92.8%, 78.9% and 98. 1%, respectively, by dual-time-point imaging. There was a statistically significant difference in the detection of lymph node metastasis between the standard singletime imaging and dual-time-point ^18F-FDG PET-CT imaging. Conclusion Dual-time-point ^18F-FDG PETCT imaging is more sensitive, specific and accurate than standard single-time ^18F-FDG PET-CT imaging in the detection of hilar and mediastinal lymph node metastasis, and may provide more information for diagnosis, staging and treatment of non-small cell lung cancer.

关 键 词：FDG PET-CT 非小细胞肺癌 双时相显像 淋巴转移 

分 类 号：R686[医药卫生—骨科学]