过敏性紫癜患儿尿中结缔组织生长因子检测及临床意义  

Urinary levels of connective tissue growth factor and its clinical significance in children with Henoch-Schonlein purpura

作　　者：范春晖[1] 孙书珍[1] 丁文捷[1] 周爱华[1] 

机构地区：[1]山东大学附属省立医院儿科肾脏风湿免疫科,山东济南250021

出　　处：《中国实用儿科杂志》2008年第4期293-294,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的评价过敏性紫癜(HSP)患儿尿中结缔组织生长因子(CTGF)水平变化的临床意义。方法将山东大学附属省立医院2006年7月至2007年3月收治的85例HSP患儿按照尿白蛋白排泄率(UAER)分成正常白蛋白尿组(Ⅰ组,25例)、微量白蛋白尿组(Ⅱ组,31例)和大量白蛋白尿组(Ⅲ组,29例),检测各组尿液CTGF,并与27名健康儿童进行比较。结果各组HSP患儿尿液CTGF质量浓度[Ⅰ组:(1.332±0.704)μg/L;Ⅱ组:(8.245±3.790)μg/L;Ⅲ组:(11.013±5.674)μg/L]显著高于对照组[(0.547±0.329)μg/L,P<0.05],HSP患儿各组间比较差异也有显著意义(P<0.05),且随着尿白蛋白排泄率的增加呈递增趋势;尿CTGF与Ⅳ型胶原、UAER呈显著正相关(r=0.495,P<0.01;r=0.542,P<0.01)。结论CTGF在紫癜性肾炎(HSPN)的发生发展中起一定的作用,尿CTGF质量浓度可作为诊断HSPN的敏感指标之一,并有助于判断病情的进展。Objective To measure the levels of urinary connective tissue growth factor（CTGF）and evaluate its clinical significances in children with Henoch-Schonlein purpura（HSP）.Methods A total of 85 children with Henoch-Schonlein purpura were divided into three groups according to urinary albumin excretion rate（UAER）：normal albuminuric group：〈20μg/min（group Ⅰ,n=25）;microalbuminuric group：20-200μg/min（group Ⅱ,n=31）;macroalbuminuric group〉200μg/min（group Ⅲ,n=29）.The urinary CTGF was determined by ELISA.Results The urinary levels of the CTGF in children with HSP were markedly higher than that in healthy controls.Moreover,the urinary levels of CTGF in children with HSP were increased with UAER,and there were significant differences among the three groups（P〈0.05）.Urinary CTGF levels were also positively correlated with collagen Ⅳ（r=0.495,P〈0.01）and UAER（r=0.542,P〈0.01）.Conclusion CTGF may play a very important role in the development of Henoch-Schonlein purpura nephritis.The urinary levels of CTGF are correlated with UAER,and may be an early marker for predicting Henoch-Schonlein purpura nephritis and accessing its severity.

关 键 词：结缔组织生长因子 紫癜性肾炎 Ⅳ型胶原 微量白蛋白尿 

分 类 号：R72[医药卫生—儿科]