维生素D受体基因多态性与小儿反复呼吸道感染的相关性研究  

Association between vitamin D receptor gene polymorphism and children patient with repeated respiratory tract infection

作　　者：王振华[1] 李丽红[1] 鲁继荣[2] 邓琳菲[1] 孙利炜[1] 

机构地区：[1]长春市儿童医院,吉林长春130061 [2]吉林大学第一医院儿科,吉林长春130021

出　　处：《中国实用儿科杂志》2008年第4期304-305,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨维生素D受体(VDR)基因BsmI位点多态性与小儿反复呼吸道感染(RRTI)的相关性,寻找RRTI的易感基因。方法应用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)技术,检测2004年3月至2006年2月长春市儿童医院97例RRTI患儿和同期于该院体检的100名健康对照组儿童血浆VDR基因BsmI位点基因型。结果RRTI组BB、Bb基因型出现频率与健康对照组相比,有增高的趋势(χ2=14.97,P<0.01)。结论维生素D受体基因多态性与小儿反复呼吸道感染的发病具有相关性。Objective To investigate the association of vitamin D receptor gene polymorphism and children patient with repeated respiratory tract infection.Methods A total of 97 children（including 50 boys and 47 girls）with RRTI aged from 6 months to 4 years（averaged 2.5 years）and 100 normal children（including 51 boys and 49 girls）were included.The vitamin D receptor gene BsmI polymorphism was detected in all subjects by polymerase chain reaction-restrictive fragment length polymorphism（PCR-RFLP）technique.Results There were three kinds of genotypes（BB,Bb,bb）of the VDR in repeated respiratory tract infection and normal children.There was a greater proportion of individuals with the BB and Bb genotype in the RRTI in comparison with the control groups（χ^2=14.97,P〈0.01）.Conclusion We find significant association between the vitamin D receptor gene BsmI and RRTI in the chilren.BB genotype is susceptibility gene of RRTI.B allele perhaps is the susceptibility gene of RRTI.

关 键 词：维生素D受体基因 反复呼吸道感染 

分 类 号：R72[医药卫生—儿科]