Calcium antagonistic effects of Bambusa Rigida investigated by ^(45)Ca and its protection on myocardial ischemia of rats  

作　　者：LIN Rushan YE Ling YANG Yuanyou LIAO Jiali MO Shangwu LIU Ning 

机构地区：[1]Key Laboratory of Radiation Physics and Technology （Sichuan University）, Ministry of Education, Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China

出　　处：《Nuclear Science and Techniques》2008年第2期99-104,共6页核技术（英文）

基　　金：National Natural Science Foundation of China (Grant No.10175044).

摘　　要：An investigation was conducted using ^(45)Ca as a radioactive tracer to evaluate calcium antagonistic effects of several extracts from Bambusa Rigida in living rats.The relationship between the flavonoid and saccharide contents of Bambusa Rigida and calcium antagonistic effects were also analyzed.The protective effects of the alkali extracts of Bambusa Rigida on myocardial ischemia were investigated in living rats.The results indicated that the alkali extracts of Bambusa Rigida had a prominent influence on Ca^(2+) influx and efflux in the isolated rat aorta and heart,as they could obviously block ^(45)Ca entering into cells and stimulate efflux of intracellular Ca^(2+).Moreover,the alkali extracts of Bambusa Rigida had favorable protective effects on myocardial ischemia induced either by isoproterenoi injection (ISO) or by the ligation of coronary artery.These results implied that the Bambusa Rigida had attractive potential for the treatment of heart,cerebrovascular and other diseases.However,the conclusion that whether the flavonoid or saccharide in Bambusa Rigida affected the calcium antagonistic effects and Ca^(2+) channels or not was hard to make within the results of the investigation.An investigation was conducted using ^45Ca as a radioactive tracer to evaluate calcium antagonistic effects of several extracts from Bambusa Rigida in living rats. The relationship between the flavonoid and saccharide contents of Bambusa Rigida and calcium antagonistic effects were also analyzed. The protective effects of the alkali extracts of Bambusa Rigida on myocardial ischemia were investigated in living rats. The results indicated that the alkali extracts of Bambusa Rigida had a prominent influence on Ca^2＋ influx and efflux in the isolated rat aorta and heart, as they could obviously block ^45Ca entering into cells and stimulate efflux of intracellular Ca^2＋. Moreover, the alkali extracts of Bambusa Rigida had favorable protective effects on myocardial ischemia induced either by isoproterenol injection （ISO） or by the ligation of coronary artery. These results implied that the Bambusa Rigida had attractive potential for the treatment of heart, cerebrovascular and other diseases. However, the conclusion that whether the flavonoid or saccharide in Bambusa Rigida affected the calcium antagonistic effects and Ca^2＋ channels or not was hard to make within the results of the investigation.

关 键 词：流入量 钙 萃取物 心肌缺血 

分 类 号：TL99[核科学技术—核技术及应用] Q4[生物学—生理学]