镇颤汤治疗肝肾不足型颤证的临床研究  

Zhenchan Decoction with Madopar for Vibration Syndrome of Gan-Shen Deficiency Syndrome

作　　者：吴成翰[1] 吴松鹰[1] 王谨敏[1] 林菊珊[1] 杨宗保[2] 范德东[1] 谢步霓[1] 林求诚[1] 

机构地区：[1]福建中医学院附属第二人民医院 [2]江西中医学院

出　　处：《中西医结合心脑血管病杂志》2008年第4期397-399,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：福建省卫生厅重点课题基金项目(No.608)

摘　　要：目的观察自拟镇颤汤合美多巴治疗肝肾不足型颤证的临床疗效。方法选择2002年3月—2007年6月门诊及住院的帕金森病(PD)和帕金森综合征(VPS)病人120例,其中PD病人56例,VPS病人64例;根据分层随机的方法,将其分为治疗组和对照组;所有病人均服用美多巴,两治疗组在美多巴的基础上再加用镇颤汤,8周为1个疗程,疗程结束后进行疗效判定。结果PD治疗组疾病疗效总有效率为93.4%,证候疗效总有效率为96.7%;PD对照组疾病疗效总有效率84.0%,证候疗效总有效率为92.0%,两组比较无统计学意义(P>0.05)。VPS治疗组疾病疗效总有效率为81.3%,证候疗效总有效率为84.4%;VPS对照组疾病疗效总有效率为43.3%,证候疗效总有效率为46.7%,两组比较有统计学意义(P<0.05或P<0.01)。两治疗组病人失眠、口干、便秘、恶心等副反应明显减少,接受美多巴治疗的依从性增加。结论自拟震颤汤对帕金森病及帕金森综合征有一定的疗效,特别是帕金森综合征,可以明显减少多巴类制剂的副反应,可以减缓美多巴制剂的追加量。Objeetive To study the therapeutic effect of Zhenchan decoction with Madopar on patients （pts） with Parkinson disease （PD） which was identified as gan-shen deficiency syndrome by traditional Chinese medicine, Methods Pts with PD or vascular Parkinson-ism （VPS） treated with Madopar were divided into the treatment group and the control group randomly, The pts in the treatment group were additionally treated with Zhenchan Decoction. Then the effect was evaluated with the 《Curative Evaluation Standard of Antiparkinson Drug》 and 《Diagnosis and Curative Evaluation Standard of Senile Paralysis of Chinese Medicine》. All the scores were added and compared pre-and post-treatment. Results There was no difference in therapeutic effec.t rate in treatment group and control group （93.4 %, 84.4 %, P〉0.05）, The symptom therapeutic effect rate, the total effective rate in treatment group and control group was 96.7 % and 92.0 %, separately. The total effective rate of the VPS treatment group was significantly higher than that of the control group （81.3 %, 43.3 %, P〈0.01）, The symptom therapeutic effect rate in the VPS treatment group was significantly higher than that in the control group （84.4%,46.7% ,P〈0.05）. The incidence rate of side-effects such as insomnia, dry mouth, nausea, constipation and emesis in the treatment group were low obviously and the compliance in treatment group was better. Conclusion Zhenchan decoction could improve the clinical therapeutic effect and reduce the dosage and side effects compared with the treatment by Madopar. The effect in pts with VPS group was better than that in pts with PD.

关 键 词：帕金森病 帕金森综合征 滋补肝肾 

分 类 号：R255[医药卫生—中医内科学]