妊娠期高血压疾病患者血浆总同型半胱氨酸浓度的监测及其影响因素分析  

Plasma total homocysteine concentration monitoring and analysis of the influencing factors in patients with pregnancy induced hypertension

作　　者：杨红星 黄素然[2] 丁少波[2] 吴雪玲[2] 张建鸿[2] 肖丽娟[2] 黎普茜[2] 

机构地区：[1]东莞市万江医院,东莞523050 [2]东莞市人民医院,东莞523018

出　　处：《中国药物应用与监测》2008年第2期1-2,15,共3页Chinese Journal of Drug Application and Monitoring

基　　金：2007年广东省科技计划项目(2007B080702046)

摘　　要：目的:监测妊娠期高血压疾病患者血浆总同型半胱氨酸(tHcy)浓度,并对其影响因素进行分析。方法:采用荧光偏振免疫分析法检测266例妊娠期高血压疾病患者和250例正常晚期妊娠妇女血浆tHcy浓度,并同时检测其血清叶酸、维生素B12(VitB12)浓度,对血浆tHcy浓度和血清叶酸、VitB12浓度的关系进行分析。结果:妊娠期高血压疾病患者血浆tHcy浓度显著高于正常妊娠组(P<0.01),且重度患者显著高于轻度患者(P<0.01),血清叶酸浓度、VitB12浓度妊娠期高血压疾病组均显著低于正常妊娠组(P<0.01)。相关分析显示,两组血浆tHcy浓度与血清叶酸、VitB12浓度均呈负相关性。结论:妊娠期高血压疾病患者血浆tHcy浓度明显升高,叶酸、VitB12缺乏可能是诱发妊娠期高血压疾病患者血浆tHcy浓度升高的重要因素之一。Objective：To analyze the monitoring results of the plasma total homocysteine （tHcy） in the patients with pregnancy induced hypertension （PIH） and discuss the influencing factors.Methods：Levels of plasma tHcy of 266 PIH patients and 250 normal late pregnancy were determined using fluorescence polarization immunoassay （FPIA）, serum folic acid and VitB12 concentrations were measured,The relationship between plasma tHcy level and levels of serum folic acid and VitB12 were analyzed.Results：The mean level of tHcy in the PIH patients was significantly higher than that in the normal controls （P〈0.01）, and the level of plasma tHcy was significantly higher in severity than that in lightness （P〈0.01）.The mean level of serum folic acid and VitB12 in PIH patients was significantly lower than that in the normal controls （P〈0.01）.Correlation analysis showed that plasma tHcy was negatively correlated with serum folic acid and VitB12.Conclusion：The level of plasma tHcy significantly elevated in patients with PIH.Deficiency of folic acid and VitB12 is one of important factors inducing hyperhomocystinemia.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 叶酸 维生素B12 

分 类 号：R714.2[医药卫生—妇产科学]