清胆颗粒高速搅拌制粒工艺的优化  

Optimize the technology of high speed wet granulation of qingdan granule

作　　者：欧灿纯 

机构地区：[1]广西省南宁市第五人民医院,南宁530001

出　　处：《中国药物应用与监测》2008年第2期22-23,共2页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:以清胆颗粒喷雾干燥浸膏粉为样本,确立最佳高速搅拌制粒处方,并对高速搅拌制粒的工艺进一步优化。方法:应用正交试验法,以颗粒均匀度为考察指标,同时兼顾颗粒中有效成分,对影响清胆颗粒高速搅拌制粒过程的因素进行考察。结果:正交试验法设计的三个因素中,乙醇的浓度对颗粒的均匀性影响最显著,PEG-10000用量也有比较显著的影响。结论:最佳工艺条件为:乙醇浓度95%,PEG-10000比例为5%,糊精则视浸膏粉量可适当调节。Objective：To establish the best prescription of high speed wet granulation, and furtherly optimize the technology by high speed wet granulation of qingdan granule for the sample copy.Methods：To utilize the orthogonal experiment, granulation uniformity and effective component for the index, influencing factors of high speed wet granulation were inspected.Results：In the three influencing factors on granulation uniformity by orthogonal experiment, the effect of the alcohol concentration was the most significant, then was the dosage of PEG-10000.Conclusion：The best condition was： 95% alcohol, 5% PEG-10000, and dosage of dextrine may be regulated by powdered extract amount.

关 键 词：清胆颗粒 高速搅拌制粒 正交试验法 

分 类 号：TQ461[化学工程—制药化工]