控制性卵巢刺激治疗中血清催乳素水平的变化特点  

Variance of serum prolactin in controlled ovarian stimulation

作　　者：梁晓燕[1] 熊永崂[1] 庄广伦[1] 

机构地区：[1]中山大学附属第一医院生殖中心,广州510080

出　　处：《中华妇产科杂志》2008年第4期254-256,共3页Chinese Journal of Obstetrics and Gynecology

基　　金：广东省科技计划重点项目（2006835901001）;广东省自然科学基金（07117364）

摘　　要：目的探讨控制性卵巢刺激（COS）治疗中血清催乳素水平的变化特点。方法收集接收体外受精．胚胎移植的患者72例，共115个周期，采用促性腺激素释放激素激动剂结合促性腺激素（Gn）长、短方案促排卵治疗，定时经阴道B超监测卵泡发育情况及子宫内膜厚度，并采用酶联免疫发光法检测不同时间点血清雌二醇、黄体生成素（LH）、孕酮和催乳素的水平，分析患者雌二醇、LH、孕酮水平与催乳素水平之间的相关性。结果对催乳素与雌二醇水平进行相关和回归分析发现，随着雌二醇水平的上升，催乳素水平有显著上升的趋势，两者呈显著正相关关系（r=0．5897，P〈0．01）。对催乳素与孕酮水平进行相关和回归分析发现，孕酮水平随催乳素水平的升高而升高，两者呈显著正相关关系（r=0.1412，P〈0．01）。但是LH水平与催乳素水平之间未见明显关联。结论在控制性卵巢刺激治疗中，催乳素的分泌不受Gn的影响，而雌二醇水平的升高可能刺激催乳素的分泌，且催乳素与孕酮水平呈正相关关系。Objective To investigate the variance of peripheral blood prolactin（PRL） in controlled ovarian stimulation. Methods Seventy-two patients, with totally 106 cycles receiving a long protocol of gonadotropin-releasing hormone agonist combined with gonadotropin （Gn） were randomly enrolled in this retrospective study. During controlled ovarian stimulation, peripheral blood hormones were measured by chemiluminescent microparticle immunoassay, Results Prolactin was positively correlated with estradiol （r=0. 5897,P 〈 0. 01 ）while there was no significant correlation between luteinizing hormone and PRL. Progesterone had a positive relation with prolactin（ r =0. 1412 ,P 〈 0. 01 ）. Conclusions During controlled ovarian stimulation, prolactin secretion is not affected by Gn but may be stimulated by estradiol. Progesterone has a positive relation with prolactin,

关 键 词：排卵诱导 催乳素 高催乳素血症 

分 类 号：R686[医药卫生—骨科学]