肝素在妊娠期疾病中的应用  

The Application of Heparin in Diseases of Gestational Period

作　　者：毛秋娴[1] 龙启才[1] 

机构地区：[1]中山市陈星海医院药剂科,广东中山528415

出　　处：《医学综述》2008年第8期1244-1246,共3页Medical Recapitulate

摘　　要：肝素系从肺提取的黏多糖硫酸酯,在体内外均有强大的抗凝作用,其解聚物低分子量肝素的量效关系更优于肝素,二者常联合广泛应用于临床。在产科领域中,它应用于包括复发性流产、妊娠期高血压疾病、妊娠合并胆汁淤积、妊娠合并心脏病、死胎等在内的多种不同的疾病,并显示出良好的治疗效果。在临床应用中,应掌握肝素应用的适应证、禁忌证,避免其副效应的发生使其最大限度地服务于临床。Heparin is mucopolysaccharide sulfate extractded from lung, which has strong anticoagulation in vivo or in vitro. Its depolymerized material is low molecular weight heparin, which has better dose-effect relationship than that of disebrin. Both of them are often combined in clinical application. It is often used in many obstetric diseases including recurrent abortion, pregnancy associated with hypertension,pregnancy associated with cholestasis, pregnancy associated with cardiac disease,dead foetus and so on,and showed good therapeutic efficacy. It is needed to grasp the indication and contraindication and avoid its adverse effect in clinic in order to make full use of it.

关 键 词：肝素 低分子量肝素 药效学 妊娠并发症 治疗 

分 类 号：R714.25[医药卫生—妇产科学] R969.3[医药卫生—临床医学]