葛根素注射液抗庆大霉素耳蜗毒性的实验研究  

The Experimental Study on the Inhibition of Gentamicin-induced Ototoxicity in Wistar Rats with Puerarin Injection

作　　者：赵慕兰[1] 

机构地区：[1]沈阳市红十字会医院耳鼻喉科,辽宁沈阳110013

出　　处：《医学综述》2008年第8期1253-1254,共2页Medical Recapitulate

摘　　要：庆大霉素是一种耳毒性药物,能够导致感音神经性聋。耳毒性药物中毒性聋与氧自由基增多密切相关,且氧自由基参与了耳蜗组织损伤及耳蜗细胞凋亡的过程。豆科植物葛根中分离出的葛根素是异黄酮类有效成分,其可直接清除氧自由基。用药物有效拮抗庆大霉素的耳毒性越来越为人们所重视。因此,用庆大霉素制作耳毒性动物模型,来探讨葛根素注射液对庆大霉素引起的耳蜗毒性的防护作用。Gentamycin is a kind of ototoxlc drug, which can bnng about hearing loss. Hearing lossderived from ototoic drug was associated with oxygen free radical which make organ and cell of conchlea inju-ried or be death. Gentamycin can take part in the progress of the form of oxygen free radical and add up the amount of oxygen free radical. The active principle of puerarin is isoflavone separated from pueraria root, a leguminous plant. The chemical compound of isoflavone clean oxygen free radical. It is necessary to study the transient ototoxic effects of gentamicin, In order to determine whether puearin also inhibits the ototoxic side effects of gentamicin, a transient ototoxic animal model was made based on the injection of a middle single dose of gentamicin and was observed for the electrocochleographic changes after administering the drug with or without simultaneous injection of puerarin.

关 键 词：葛根素 庆大霉素 耳蜗 自由基 

分 类 号：R764.35[医药卫生—耳鼻咽喉科] R-33[医药卫生—临床医学]