辛伐他汀在糖调节受损人群干预颈动脉中膜厚度的研究  

Effect of Stimvastatin on Carotid Intima-media Thickness in Chinese Popuation with Impaired Glucose Regulation

作　　者：王专运[1] 郝清顺[1] 

机构地区：[1]山东省枣庄市立医院内分泌科,山东枣庄277102

出　　处：《河北医学》2008年第4期392-396,共5页Hebei Medicine

摘　　要：目的:了解不同糖调节受损(IGR)患者颈动脉中膜厚度(IMT)的差异性,明确IMT的危险因素及观察辛伐他汀对IMT影响。方法:收集新诊断220例IGR患者及160例正常糖耐量人群的临床资料:包括年龄、性别、体重指数、血压、空腹及餐后血糖(OGTT)、空腹血脂、WHR、HOMA-IR等指标,并应用彩色DopplerB型超声测量所有研究对象的IMT,分析不同糖调节受损状态患者IMT差异性。将IGT组及IFG+IGT组患者混合后随机分成对照组和辛伐他汀干预组,6个月、1年后观察两组IMT的变化。结果:①IGT组及IFG+IGT组IMT分别与IFG组及NGT组分别比较有显著差异(p<0.01),其他各组比较无显著差异(p>0.05)。②多元素回归分析显示:IMT与年龄、收缩压、TC、LDL-C、WHR、2hPG、HOMA-IR呈显著相关(p<0.05,p<0.01)。③6个月、1年后所有IGT及IFG+IGT患者IMT均较治疗前有所增厚,但辛伐他汀治疗组较对照组增加缓慢,两组IMT有显著差异(p<0.05)。结论:与正常人群比较,IGR组中的IGT、IFG+IGT的IMT已经增厚,而辛伐他汀可以延缓IGR患者早期动脉硬化(AS)进展。Objective： To investigate the diversity of carotid intima-media thickness（IMT） in patients with different impaired glucose regulation （IGR）, to definite the risk factors of IMT, and observe the effect of simvastatin on IMT. Method： The clinical data of 220 IGR patients and 160 controls with normal oral glucose tolerance were collected, including age, sex, BMI, blood pressure, fasting and postprandial blood glucose （OGTF）, fasting lipid, WHR, HOMA-IR, etc. IMT was assessed with color doppler ultrasonography in all cases, meanwhile the diversity of IMT in patients with different IGR was analysis. After IGT group and IFG ＋ IGT group were mixed, the patients were divided into simvastatin group and control group at random. The changes of IMT were observed after treatment for 6 months and 12 months. Results： ①There were significant differences in IMT between IGT/IFG ＋ IGT group and IFG/NGT groups （ P 〈 0.01 ） , and no obvious difference between other groups（ P 〉 0.05 ）. ② IMT was closely related to age, SBP, TC, LDL - C, WHR, 2hPG, and HOMA-IR. ③The IMT in patients with IGT/IFG ＋ IGT were significandy increased after treatment for 6 months as compared with before treatment. However in contrast to the control group, there was increased slowly in simvastatin group. The difference in IMT was significant between the two groups （ P 〈 0. 05 ）. Conclusion： The IMT in patients with IGT/IFG ＋ IGT were thicker than the normal control group. Simvastatin can prevent the development of early atherosclerosis in patients with IGR.

关 键 词：辛伐他汀 糖调节受损 颈动脉中膜厚度 

分 类 号：R543[医药卫生—心血管疾病]