银杏达莫注射液治疗糖尿病性周围神经病的疗效观察  

Clinical study on efficacy of Xingding Ginkgo-Dipyridamolum on diabetic peripheral neuropathy

作　　者：迟兰芹[1] 王平[1] 陈永清[1] 

机构地区：[1]烟台市莱阳中心医院神经内科,山东烟台265200

出　　处：《临床和实验医学杂志》2008年第4期63-65,共3页Journal of Clinical and Experimental Medicine

摘　　要：目的评价银杏达莫注射液治疗糖尿病性周围神经病的疗效及安全性。方法105例糖尿病性周围神经病变患者,随机进入银杏达莫组(53例),维生素B1和维生素B12组(52例)。银杏达莫组每天静脉滴注银杏达莫注射液20ml(5ml/支)于生理盐水250ml中,共2周。维生素B1和维生素B12组每天肌内注射维生素B1注射液100mg和维生素B12注射液500μg,共2周。比较两组治疗前后症状,体征。神经传导速度的变化及不良反应。结果治疗2周后,两组的神经功能缺失评分(CSS)评分皆有明显降低,与对照组相比,治疗组患者症状,体征明显改善,总有效率(显效+有效)81.1%,与对照组总有效率57.7%相比较,差异有显著性。感觉及运动神经传导速度显著提高。无严重不良反应。结论银杏达莫对糖尿病性周围神经病有较好疗效。Objective To evaluate the efficacy of Xingding Ginkgo - Dipyridamolum in treatment of diabetic peripheral neuropathy （DPN） in patients with type 2 diabetes mellitus in comparison with that of VitB1 ,VitB12. Methods One hundred and five patients with DPN in Laiyang Central Hospital were randomly allocated into two groups： 53 cases in Xingding Ginkgo - Dipyridamolum group （ with 20 ml, iv drip, QD for 2 weeks） and 52 cases in VitB1 and VitB12greup （ with VitB1 100mg and VitBl2 500 μg, im for 2 weeks）. Results Clinical symptoms of DPN in patients with type 2 diabetes mellitus were significantly improved after the treatment of Xingding Ginkgo - Dipyridamolum for 2 weeks, and the effective rate was 81.1% in comparison with that of 57.7% in control group. After Xingding Ginkgo -Dipyridamolum treatment, nerve conduction velocity （NCV） had been significantly improved in comparison with that before treatment. Conclusion Xingding Ginkgo - Dipyridamolum is effective in improving the clinical symptoms and NCV in patients with DPN.

关 键 词：银杏达莫注射液 糖尿病性周围神经病 神经传导速度 

分 类 号：R259[医药卫生—中西医结合]