支气管哮喘患儿血清IL-6、IL-8、TNF的变化及临床意义  

Changes and clinical significance of serum IL-6,IL-8 and TNF in children affected with bronchial asthma

作　　者：杨丽华[1] 辛长顺[1] 齐娜[1] 

机构地区：[1]吉林大学第四医院儿科,吉林省长春市130011

出　　处：《中国厂矿医学》2008年第2期139-140,共2页Chinese Medicine of Factory and Mine

摘　　要：目的探讨支气管哮喘患儿血清白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF)水平的变化及临床意义。方法应用放射免疫分析法分别测定34例哮喘急性发作期、30例哮喘缓解期患儿血清中IL-6、IL-8、TNF水平,并设28例健康儿童为对照组。结果哮喘急性发作期患儿血清中IL-6、IL-8、TNF平均水平明显高于哮喘缓解期及对照组,差异非常显著(P<0.001)。哮喘缓解期患儿血清中IL-6、IL-8、TNF水平仍高于对照组,差异显著(P<0.01)。结论不同时期支气管哮喘患儿血清中IL-6、IL-8、TNF水平的变化对探讨哮喘发病机制、病情进展及指导用药具有十分重要的临床价值。Objective To discuss the changes and clinical significance of serum interleukin-6 （IL-6）, interleukin-8 （IL-8） and tumor necrosis factor （TNF） in children suffered from bronchial asthma. Methods Control analyses were performed for acute attack stage （ attack stage group, 34 cases）, remission stage （remission stage group, 30 cases） of bronchial asthma children and healthy children （control group, 28 cases）. Differences among three groups were calculated using t test. The levels of serum IL-6, IL-8 and TNF were respectively measured by radioimmunoassay in each group. Results The levels of serum IL-6, IL-8 and TNF were all significantly higher in acute attack group compared with in remission stage group and control group （ P 〈0. 001 ） and also higher in remission stage group than those of control group （P 〈0. 01 ）. Conclusions The changes of serum IL-6, IL-8 and TNF levels in different stages of asthma can contribute important value to researching pathogenesis, ascertaining disease condition and guiding medication.

关 键 词：支气管哮喘 白细胞介素-6 白细胞介素-8 肿瘤坏死因子 

分 类 号：R562.25[医药卫生—呼吸系统]