血管紧张素Ⅱ1型受体基因多态性与冠心病发病相关  

AngⅡtype 1 receptor Polymorphism is association with Coronary artery disease

作　　者：杨涛[1] 石毅[1] 陈敬州[1] 李阳[2] 白永怿[1] 王虎[1] 孙凯[1] 刘峻豪[1] 秦勤[2] 惠汝太 

机构地区：[1]中国医学科学院阜外心血管病医院教育部心血管病基因与临床研究重点实验室中德实验室,北京100037 [2]天津市胸科医院,天津300051

出　　处：《中国分子心脏病学杂志》2008年第2期91-94,共4页Molecular Cardiology of China

基　　金：科技部国际合作项目(编号:2006DFA31500);国家自然科学基金(编号:30640080)

摘　　要：目的研究血管紧张素Ⅱ1型受体基因多态性是否与冠心病的发病相关。方法通过冠状动脉造影检查,共收集了455例冠心病患者和465例对照。采用等位基因特异性PCR对血管紧张素Ⅱ1型受体SNP位点rs5186(A1166C)进行基因分型,最后进行统计分析。结果共检测了455例冠心病患者和465例对照。基因分型结果显示,在冠心病病人和对照之间,SNP rs5186基因型存在差异,AA基因型降低冠心病的发病风(OR=0.57,P<0.001)。结论血管紧张素Ⅱ1型受体基因多态性与冠心病的发病相关,SNP 1166AA是冠心病发病的保护因素。Objective To study relationship between polymorphism of Ang Ⅱ type 1 receptor and incidence of coronary artery disease. Methods With coronary arteriongraphy, 455 patients and 465 control were collected. Genetyped SNP rsS186 （A1166C ） with PCR amplification involving allele-specific oligonucleotides （ASO）. Result Total of 455 patients with CAD and 465 control were investigated. Genetype between CAD and control had difference. In people with genetype AA, the risk of CAD reduced （ OR = 0.57, P 〈 0. 001 ）. Conclusion Incidence of coronary artery disease correlated with polymorphism of Ang Ⅱ type 1 receptor, SNP 1166AA was protected factor of CAD.

关 键 词：血管紧张素Ⅱ受体 多态性 冠心病 MicmRNA 

分 类 号：R541.4[医药卫生—心血管疾病]