芪丹煎剂抗胃癌转移的配伍研究  

The combination study of Qidan Decoction on inhibiting gastric cancer metastasis

作　　者：余绍蕾[1] 蔡宇[1] 冯笑珍[1] 张荣华[1] 

机构地区：[1]暨南大学药学院,广东广州510632

出　　处：《中成药》2008年第4期487-489,共3页Chinese Traditional Patent Medicine

基　　金：广东省科技项目(2005B30101011)

摘　　要：目的:研究芪丹煎剂(黄芪、丹参、补骨脂等)抗胃癌转移的组方配伍合理性及最佳组合。方法:从肿瘤细胞转移抑制率和NK细胞活性两方面对芪丹煎剂的处方组成进行配伍研究。结果:黄芪、丹参、补骨脂和枸杞对胃癌转移抑制率和提高NK细胞活性的作用有统计学意义(P<0.05)。结论:芪丹煎剂中抑制胃癌细胞转移和提高机体免疫的最主要因素是药材黄芪,其次是丹参、补骨脂、枸杞。AIM： To study the rationality and the best dosage of Qidan Decoction （Radix Astragali, Radix et Rhizoma Salviae miltiorrhizae, Fructus Psoraleae, etc. ） on inhibiting gastric cancer metastasis. METHODS： The ability of inhibiting gastric cancer metastasis and the activity of NK cell were detected as indexes to appraise the rational and the best dosage. RESULTS： The function of Astragalus membranaceus ,Salvia miltiorrhiza. Ege. , psoralea corylifolia and Lycium Barbarum on inhibiting gastric cancer metastasis and rising the activity of NK cell was significant （ P 〈 0.05 ）. CONCLUSION ： Astragalus membranaceus is the most important factor in inhibiting cancer metastasis ,followed by Salvia miltiorrhiza. Bge. , psoralea corylifolia and Lycium Barbarum.

关 键 词：芪丹煎剂 抗转移 正交设计 

分 类 号：R285.6[医药卫生—中药学]