一种新型抗钙化处理的人工生物瓣膜流体力学性能  

Fluid dynamics of a novel anti-calcification treated bioprosthetic heart valve

作　　者：张涛[1] 周建业[1] 胡盛寿[1] 刘立群[2] 雷荣军[3] 汪胜 

机构地区：[1]中国医学科学院中国协和医科大学阜外心血管病医院再生医学研究室,北京100037 [2]潍坊医学院附属医院胸心外科,山东潍坊261031 [3]北京市普惠生物医学工程公司,北京100037

出　　处：《北京生物医学工程》2008年第2期123-126,共4页Beijing Biomedical Engineering

基　　金：北京市科技计划课题(Y0405003040291)资助

摘　　要：目的评价一种新型生物瓣膜的体外流体力学性能,并与传统生物瓣膜及机械瓣膜进行比较。方法将测试瓣膜分成三组:新型生物瓣组(GA+SOB处理牛心包瓣),传统生物瓣组(单纯GA处理牛心包瓣),机械瓣组(双叶瓣),每组分别选21号、25号、29号三种型号,采用清华大学TH-1200脉动流测试仪,按照ISO5840瓣膜检测标准进行流体性能检测,包括跨瓣压差、返流量、返流百分比及有效开口面积,并进行组间的分析、比较。结果新型生物瓣膜的前向流跨瓣压差较传统生物瓣小17%～30%,较机械瓣小23%～50%;新型生物瓣的有效开口面积较传统生物瓣和机械瓣分别大13%～37%和36%～50%;新型生物瓣的返流量较传统生物瓣大1.2～2.0mL,约3%～6%;较机械瓣小0.9～2.8mL,约1.3%～5%。结论新型人工生物瓣膜具有良好的血流动力学性能。Objective To evaluate the hydrodynamic characteristics of a novel anti-calcification treated bioprosthetic heart valve and compare them with those of conventional bioprosthetic and mechanical heart valves. Methods All measurements were performed at the simulative aortic position of a TH-1200 pulse duplicator. The objects of 21mm,25mm, 29mm in diameter from three groups of the novel anti-calcification treated bovine pericardial, the conventional bovine pericardial and the bi-leaflets mechanical heart valves were tested. The pressure difference, regurgitant volume, regurgitant fraction and effective＇orifice area of each valve were recorded and calculated, Results The novel bioprostheses were 17% 30% lower in pressure difference than those of traditional bioprostheses and 23% - 50% lower than those of mechanical prostheses. The effective orifice areas were 13% -37% greater than bioprostheses and 36% -50% greater than mechanical. The novel bioprostheses had 1,2 - 2,0mL greater regurgitant volume than those of conventional bioprostheses whereas 0, 9 -2.8mL lower than those of mechanical prostheses. The regurgitant fraction of the novel bioprostheses is 3% -6% greater than bioprostheses and 1.3% - 5% lower than mechanical. Conclusion The anti-calcification treated bioprosthetic heart valves are of excellent hydrodynamic properties.

关 键 词：人工生物瓣膜 流体力学 脉动流测试仪 

分 类 号：R318.01[医药卫生—生物医学工程]