不同时间犬缺血心肌对^(99)Tc^m-MIBI摄取比值的观察  

Observation on (99)Tc^m-MIBI Uptake of Ischemic Myocardium in Dog Models After Left Circumflex Coronary Artery Constriction

作　　者：程光华[1] 戴云海[1] 吴克芳[1] 徐泉凤[1] 

机构地区：[1]皖南医学院弋矶山医院核医学科,241001

出　　处：《放射免疫学杂志》2008年第2期105-106,共2页Journal of Radioimmanology

摘　　要：目的:观察犬冠状动脉左旋支狭窄后心肌细胞对99锝m-甲氧基异丁基异腈(99Tcm-MIBI)摄取与时间变化之间的关系。方法:建立犬冠状动脉左旋支狭窄模型(12只),分别注射99Tcm-MIBI,剂量为185MBq(5mCi)。注射1h和4h后,各处死6只犬,取出心脏,于左室侧壁(缺血区)和前壁(正常区)分别取心肌组织约100mg,用γ计数器测定其放射性计数,换算成每克组织放射性计数值,求出侧壁与前壁放射性比值。结果:注射后1h犬左心室缺血区与正常区组织放射性计数比值为0.726±0.054,4h为0.673±0.080,两者之间比较差异无显著性(t=1.3452,P>0.05)。结论:延长时间不能提高缺血心肌对99Tcm-MIBI摄取比。Objective To observe 99Tc^m= - MIBI uptake of ischemic myocardium at different times （ lh, 4h） in dog models after left circumflex coronary artery constriction. Methods 12 dog models of coronary artery stenesis were prepared by left circumflex coronary ligation, and were given injection of 99Tc^m= - MIBI at the dosage of 185 MBq （SmCi）. Six models were sacrificed at one hour and four hours after the injection respectively. Radio - uptake in about 100mg myocardium from both ischemic and non - ischemic sites were measured with r - counter. Results No significant differences were found between ratios of radioactive count of ischemic over normal myocardial tissues at lh and 4h after injection of 99Tc^m-MIBI （0. 726 ± 0. 054 and 0.673 ± 0.080, respective, t = 1. 3452, P 〉 0.05）. Conclusion The extension of pest - injection time would not increase 99Tc^m-MIBI uptake in ischemic myocardium.

关 键 词：缺血心肌 ^99锝^m-甲氧基异丁基异腈 摄取比值 犬冠状动脉左旋支狭窄 

分 类 号：R542.2[医药卫生—心血管疾病] R817.4[医药卫生—内科学]